NRG-1 promotes megalin-involved Cbl uptake after which Cbl undergoes dealkylation
or decyanation, giving rise to Cbl(II) and subsequently to OHCbl.
The rather unexpected C-C bond cleavage reaction was regarded as a biomimetic version of the phytosterol dealkylation
Structural study shows that thermal cracking of asphaltenes follow dealkylation
The differences in product yields are too great to be explained by some certain reaction mechanism such as dealkylation
, cyclization and dehydrogenation of volatile components or addition.
Microbial degradation of prometryne takes place with the oxidation of the methylthio group to hydroxy metabolites, and dealkylation
of the side chains (Tomlin 1994).
9] recently demonstrated that both full-length and alternatively spliced forms of MS are complexed with MMACHC, and human MMACHC carries out GSH-dependent dealkylation
of MeCbl to yield OHCb .
In water systems, ATZ typically undergoes dealkylation
to form desethylatrazine (DEA), desisopropylatrazine (DIA), and the terminal dealklylation product diaminochlorotriazine (DACT) (Nelson et al.
identify and develop a process for dealkylation
of higher alkyl phenols
Because organisms are exposed to various sources of organotins and these chemicals undergo dealkylation
in vivo, cells in tissues are generally exposed to a mixture of organotins.
This suggests that the dealkylation
of ethylmercury is much more extensive than that of MeHg.
Methadone is extensively metabolized by hydroxylation and dealkylation
of the nitrogen methyl groups; these dealkylated metabolites are unstable and spontaneously cyclize to form 2-ethylene1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), which may further N-demethylate (1).
The CYP1A1 and CYP2B1 activities in lung microsomes were determined by monitoring the dealkylation
of EROD or PROD, respectively.