NRG-1 promotes megalin-involved Cbl uptake after which Cbl undergoes
dealkylation or decyanation, giving rise to Cbl(II) and subsequently to OHCbl.
We started the study on the
dealkylation mechanism around 1968, since we possessed a sizable amount of fucosterol (6), available from brown algae such as Sargassum ringgoldianum through our search for marine resources.
Structural study shows that thermal cracking of asphaltenes follow
dealkylation reactions.
Desethylatrazine, which is formed by microbial
dealkylation of atrazine, has a water solubility that is two orders of magnitude larger than that of atrazine - 3,200 ppm at 22 [degrees] C (Mills and Thurman 1994) - and is as persistent as the parent compound (Thurman et al.
In aerobic soils, it is much longer lived, undergoing oxidative
dealkylation over a period of months to years, depending on conditions.
Benzyloxyresorufin- (BROD), ethoxyresorufin- (EROD), methoxyresorufin- (MROD), and pentoxyresorufin-O-
dealkylation (PROD) were determined as described by Burke et al.
These radicals attack indiscriminately all species present in the reaction, oxidizing organic compounds by abstraction of hydrogen or engaging in double bonds and aromatic rings (hydroxylation), causing reactions such as demethoxylation, dehalogenation,
dealkylation, denitration, deamination and decarboxylation [5, 6].
Further
dealkylation of the CHQ side chain results in the production of 7-chloro-4-aminoquinoline (55-56).
The differences can be interpreted as an increase in
dealkylation reactions relative to dehydrogenation and cyclization during pyrolysis of BKT II.
Microbial degradation of prometryne takes place with the oxidation of the methylthio group to hydroxy metabolites, and
dealkylation of the side chains (Tomlin 1994).
[9] recently demonstrated that both full-length and alternatively spliced forms of MS are complexed with MMACHC, and human MMACHC carries out GSH-dependent
dealkylation of MeCbl to yield OHCb [17].
Mass defect filtering was set with a mass tolerance of 40 mDa for metabolites similar to the parent drug or with major modifications, e.g.,
dealkylation or glucuronidation, which would markedly change the mass defect (Table 1).
