NRG-1 promotes megalin-involved Cbl uptake after which Cbl undergoes
dealkylation or decyanation, giving rise to Cbl(II) and subsequently to OHCbl.
The rather unexpected C-C bond cleavage reaction was regarded as a biomimetic version of the phytosterol
dealkylation.
Structural study shows that thermal cracking of asphaltenes follow
dealkylation reactions.
The differences in product yields are too great to be explained by some certain reaction mechanism such as
dealkylation, cyclization and dehydrogenation of volatile components or addition.
Microbial degradation of prometryne takes place with the oxidation of the methylthio group to hydroxy metabolites, and
dealkylation of the side chains (Tomlin 1994).
9] recently demonstrated that both full-length and alternatively spliced forms of MS are complexed with MMACHC, and human MMACHC carries out GSH-dependent
dealkylation of MeCbl to yield OHCb [17].
In water systems, ATZ typically undergoes
dealkylation to form desethylatrazine (DEA), desisopropylatrazine (DIA), and the terminal dealklylation product diaminochlorotriazine (DACT) (Nelson et al.
identify and develop a process for
dealkylation of higher alkyl phenols
Because organisms are exposed to various sources of organotins and these chemicals undergo
dealkylation in vivo, cells in tissues are generally exposed to a mixture of organotins.
This suggests that the
dealkylation of ethylmercury is much more extensive than that of MeHg.
Methadone is extensively metabolized by hydroxylation and
dealkylation of the nitrogen methyl groups; these dealkylated metabolites are unstable and spontaneously cyclize to form 2-ethylene1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), which may further N-demethylate (1).
The CYP1A1 and CYP2B1 activities in lung microsomes were determined by monitoring the
dealkylation of EROD or PROD, respectively.
