alkylation

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al·kyl·a·tion

(al'ki-lā'shŭn),
Substitution of an alkyl radical for a hydrogen atom; for example, introduction of a side chain into an aromatic compound.

alkylation

/al·kyl·a·tion/ (al″kĭ-la´shun) the substitution of an alkyl group for an active hydrogen atom in an organic compound.

alkylation

a chemical reaction in which an alkyl group is transferred from an alkylating agent. When such organic reactions occur with a biologically significant cellular constituent such as deoxyribonucleic acid, they result in interference with mitosis and cell division.

al·kyl·a·tion

(al'ki-lā'shŭn)
Substitution of an alkyl radical for a hydrogen atom; e.g., introduction of a side chain into an aromatic compound.
References in periodicals archive ?
NRG-1 promotes megalin-involved Cbl uptake after which Cbl undergoes dealkylation or decyanation, giving rise to Cbl(II) and subsequently to OHCbl.
The rather unexpected C-C bond cleavage reaction was regarded as a biomimetic version of the phytosterol dealkylation.
Structural study shows that thermal cracking of asphaltenes follow dealkylation reactions.
The differences in product yields are too great to be explained by some certain reaction mechanism such as dealkylation, cyclization and dehydrogenation of volatile components or addition.
Microbial degradation of prometryne takes place with the oxidation of the methylthio group to hydroxy metabolites, and dealkylation of the side chains (Tomlin 1994).
9] recently demonstrated that both full-length and alternatively spliced forms of MS are complexed with MMACHC, and human MMACHC carries out GSH-dependent dealkylation of MeCbl to yield OHCb [17].
In water systems, ATZ typically undergoes dealkylation to form desethylatrazine (DEA), desisopropylatrazine (DIA), and the terminal dealklylation product diaminochlorotriazine (DACT) (Nelson et al.
Because organisms are exposed to various sources of organotins and these chemicals undergo dealkylation in vivo, cells in tissues are generally exposed to a mixture of organotins.
This suggests that the dealkylation of ethylmercury is much more extensive than that of MeHg.
Methadone is extensively metabolized by hydroxylation and dealkylation of the nitrogen methyl groups; these dealkylated metabolites are unstable and spontaneously cyclize to form 2-ethylene1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), which may further N-demethylate (1).
The CYP1A1 and CYP2B1 activities in lung microsomes were determined by monitoring the dealkylation of EROD or PROD, respectively.