DAZ1

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DAZ1

A gene on chromosome Yq11.223 that encodes an RNA-binding protein expressed only in premeiotic germ cells, especially in spermatogonia, which plays an essential role in spermatogenesis, possibly by binding to the 3’-UTR of mRNAs and regulating their translation. DAZ1 promotes germ cell progression to meiosis and formation of haploid germ cells, and it is a candidate for Y-chromosomal azoospermia factor. It forms a heterodimer with BOLL and DAZL, and interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.

Molecular pathology
Defects in DAZ1 cause spermatogenic failure Y-linked type 2.
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Los genes analizados, mediante PCR multiplex, contenidos en cada STSs, por cada Multiplex master mix A (DAZ, DYS240, DYS271, DYS221, KAL-Y, y control interno SMCX); Multiplex master mix B (SMCY, DYS218, DAZ2 Y DAZ3, y control interno SMCX); Multiplex master mix C (DYS219, DYS212, DYF51S1, DAZ4 Y control interno SMCX); Multiplex master mix D (DYS223, DYS236,DYS215, y control interno SMCX) y Multiplex master mix E (SRY, DYS224, DYS148, DYS273 y control interno ZFX/ZFY).
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