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(nit-a-zox-a-nide) ,


(trade name)


Therapeutic: antiprotozoals
Pharmacologic: benzamides
Pregnancy Category: B


Treatment of diarrhea due to Cryptosporidium parvum and Giardia lamblia.Not effective for C. Parvum diarrhea in HIV-infected patients.


Interferes with electron transfer reaction necessary for anaerobic energy metabolism of offending organisms.

Therapeutic effects

Antiprotozoal action resulting in decreased diarrhea.


Absorption: Following oral administration, nitazoxanide is rapidly converted to tizoxanide which is the active metabolite; tizoxanide is further metabolized.
Distribution: Unknown.
Protein Binding: >99%.
Metabolism and Excretion: Tizoxanide—excreted in urine, bile and feces; inactive metabolites excreted in urine, bile and feces.
Half-life: Unknown.

Time/action profile (blood levels)

POunknown†1–4 hr12 hr
†Onset of antidiarrheal activity is 24–48 hr


Contraindicated in: Hypersensitivity.
Use Cautiously in: Hepatic and/or renal impairment; Diabetics (contains 1.48 g sucrose/5 mL); Children <1 pregnancy or lactation (safety not established).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness

Ear, Eye, Nose, Throat

  • yellow eye discoloration


  • abdominal pain
  • diarrhea
  • vomiting


  • discolored urine


  • pruritus
  • sweating


  • fever


Drug-Drug interaction

May interact with other highly protein-bound drugs by competing for binding sites.


Oral (Adults and children ≥ 12 yr) 500 mg every 12 hr for 3 days.
Oral (Children 4–11 yr) 200 mg (10 mL) every 12 hr for 3 days.
Oral (Children 1–4 yr) 100 mg (5 mL) every 12 hr for 3 days.


Tablets: 500 mg
Oral suspensionstrawberry: 100 mg/5 mL in 60 mL bottle

Nursing implications

Nursing assessment

  • Assess frequency and consistency of stools and bowel sounds before and during therapy.
  • Assess fluid and electrolyte balance and skin turgor for dehydration.

Potential Nursing Diagnoses

Diarrhea (Indications)


  • Oral: Administer with food. Keep container tightly closed and shake well before each administration. Suspension may be stored at room temperature for 7 days; discard unused portion.
    • Pedi: Tablets contain more than pediatric dose; use solution for patients ≤12 years.

Patient/Family Teaching

  • Explain to parents administration of medication and monitoring of condition.

Evaluation/Desired Outcomes

  • Resolution of symptoms: no watery stools, no more than 2 soft stools within the past 24 hr and no unformed stools within the past 48 hr.


an antiprotozoal agent used to treat diarrhea caused by Cryptosporidium parvum or Giardia lamblia.


A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.


A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
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