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A widely distributed infectious disease caused by Histoplasma capsulatum; occurs occasionally in outbreaks; usually acquired by inhalation of spores of the fungus in soil dust and manifested by a self-limited pneumonia. In patients with emphysema, infection may be chronic and cause pulmonary fibrocavitary disease resembling tuberculosis; in immunosuppressed patients, and rarely, in otherwise healthy persons, histoplasmosis may cause disseminated disease of the reticuloendothelial system, which is manifested by fever, emaciation, splenomegaly, and leukopenia.
Synonym(s): Darling disease
[Samuel Taylor Darling, U.S. pathologist, 1872–1925]Histoplasmosis.
Darling,Samuel Taylor, U.S. physician in Panama, 1872-1925.
Darling disease - a widely distributed infectious disease caused by Histoplasma capsulatum and manifested by a primary benign pneumonitis. Synonym(s): histoplasmosis