keratosis follicularis(redirected from Darier Disease)
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Related to Darier Disease: lichen planus, keratosis follicularis
Darier-White syndromeA rare autosomal dominant disorder of keratinisation characterised by multiple focal keratotic papules with acantholytic dyskeratosis. It first appears in childhood or adolescence with the formation of numerous flesh-colored papules in sebaceous areas of the skin glands—chest, scalp, forehead, back, ears, groin, nasolabial folds—which, with time, become encrusted. The nails are dystrophic, palms possibly pitted; variable retinitis pigmentosa and cataracts.
Defect in the desmosome-keratin filament complex due to ATP2A2 mutations.
ker·a·to·sis fol·lic·u·la·ris(ker'ă-tō'sis fŏ-lik'yū-lā'ris)
keratosis(ker?a-to'sis) (-to'sez?) plural.keratoses [ kerato- + -osis]
actinic keratosisAbbreviation: AK
Liquid nitrogen destroys these lesions and prevents them from progressing to other cancers of the skin.
keratosis follicularisDarier's disease.
keratosis nigricansAcanthosis nigricans.
keratosis palmaris et plantaris
The disorder is characterized by an accumulation of horny material at follicular orifices of persons with rough, dry skin. It is most pronounced in winter on lateral aspects of thighs and upper arms with possible extension to legs, forearms, and scalp.
There is no specific therapy, but keratolytic lotions may be of some value.
Keratoid, nevoid, acanthoid, or verrucose types occur in older adults and in those with long-standing dry seborrhea, on the face, scalp, interscapular or sternal regions, and backs of the hands. The yellow, gray, or brown sharply circumscribed lesions are covered with a firmly adherent scale, greasy or velvety on the trunk or scalp but harsh, rough, and dry on the face or hands.
Thorough curettage is effective. This leaves a flat surface that becomes covered with normal skin within about 1 week. Pedunculated lesions can be removed surgically. Cautery may produce scarring and should not be used.
smokeless tobacco keratosisTobacco pouch keratosis.
snuff keratosisTobacco pouch keratosis.
solar keratosisActinic keratosis.
tobacco pouch keratosis
keratosis follicularisSee DARIER'S DISEASE.
Darier,Jean Ferdinand, Hungarian-born French dermatologist, 1856-1938.
diseasepathogenic entity characterized by an identifiable aetiological agent, group of signs and symptoms and/or consistent anatomical alterations; see syndrome
Darier's disease; keratosis follicularis progressive autosomal-dominant disorder of keratinization characterized by dark, coalescent, papillomatous/warty epidermal growths