It is called as Darier's sign
(Thamm and Vail, 2001).
Clinical features appear within the first two years of life, in the form of multiple oval or round hyperpigmented macules, papules, or patches that are brown-red-yellow and 2-4 mm in diameter.11 They urticate within a few minutes of gentle rubbing (Darier's sign) causing localized itch, redness, and wealing, which subsides within an hour.
On stroking the individual lesion, there was formation of a weals and erythema in addition to severe itching (Darier's sign positive), (Figure 2).
The lesion did not become swollen, itchy, and red when stroked (negative Darier's sign
In cutaneous lesions, erythema and urticaria may develop around the lesion with physical trauma including rubbing and friction; this is called "Darier's sign
This is known as Darier's sign
. The urticarial lesions can progress to become fluid-filled blisters.
(the development of a hive or wheal when a lesion is stroked) was present.
. Indian J Dermatol Venereol Leprol 2007; 73: 363-4.
More than 80% of patients with cutaneous mastocytosis exhibit characteristic brown, red, or orange macules, papules, and rarely nodules that demonstrate a positive Darier's sign
(wheeling and reddening of lesions with stroking or rubbing).
Patients with hyperpigmented lesions should have the skin stroked firmly to elicit Darier's sign
suggestive of cutaneous mastocytosis and a baseline serum tryptase level to rule out mastocytosis along with a lesional biopsy should be performed, if indicated.
On gentle stroking, the lesions turned significantly erythematous (Darier's sign
"Any orange-brown lesion deserves a firm stroke to see if Darier's sign
is present," said Dr.