Darier's disease


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Related to Darier's disease: lichen planus

keratosis

 [ker″ah-to´sis]
any horny growth, such as a wart or callosity.
actinic keratosis a sharply outlined wartlike or keratotic growth, which may develop into a cutaneous horn, and may become malignant; it usually occurs in the middle aged or elderly and is due to excessive exposure to the sun. Called also senile or solar keratosis. (See Atlas 3, Part F).
keratosis follicula´ris a slowly progressive autosomal dominant disorder of keratinization characterized by pinkish to tan or skin-colored papules on the seborrheic areas of the body that coalesce to form plaques, which may become crusted and secondarily infected; over time, the lesions may become darker and may fuse to form papillomatous and warty malodorous growths. Called also Darier's disease and Darier-White disease.
keratosis palma´ris et planta´ris palmoplantar keratoderma.
keratosis pharyn´gea horny projections from the tonsils and pharyngeal walls. Called also pharyngokeratosis.
keratosis pila´ris hyperkeratosis limited to the hair follicles.
keratosis puncta´ta a hereditary hyperkeratosis in which the lesions are localized in multiple points on the palms and soles.
seborrheic keratosis (keratosis seborrhe´ica) a benign, noninvasive tumor of epidermal origin, marked by numerous yellow or brown, sharply marginated, oval, raised lesions.
senile keratosis (solar keratosis) actinic keratosis.

Darier's disease

Keratosis follicularis, a rare autosomal dominant skin disease caused by mutations on Chromosome 12. It features warty, foul-smelling plaques formed of coalesced greasy plaques of seborrhoeic dermatitis with severe itching and sometimes pain. The disease is chronic and may worsen with age. Treatment is with oral retinoids. Prenatal diagnosis by DNA analysis of cells obtained by chorionic villus sampling is possible.
References in periodicals archive ?
She had first presented with a psychotic episode at the age of 21 years, and was diagnosed with Darier's disease at the age of 17 years.
Histological characterization of Darier's disease in Tunisian families.
The intertriginous acantholytic dermatosis is a different clinical entity from Haley-Haley disease and intertriginous Darier's disease, although similar histopathological changes can be found.
Bale, "Darier's disease associated with cutaneous malignancies," Journal of Dermatologic Surgery and Oncology, vol.
Darier's disease (DD) is a rare congenital acantholytic disorder transmitted as an autosomal dominant trait.
With Darier's disease, skin lesions are often present in the second decade of life but rarely appear in adulthood.
(5,6,7) However changes of erythronychia along with distil notching of the nail plate like that of Darier's disease can be present in subungual glomus tumor as seen in our patient.
CONCLUSION: This case is reported for its uniqueness in conformity with the criteria enunciated by Stulli associated with hyperkeratotic warty papules clinically fitting into Darier's disease. Another interesting feature being acquired black pigmentation of fingers and nails which was due to cashew shell paste application mistaken for dry gangrene was saved.
Background Darier's disease is an uncommon inherited skin disease transmitted in autosomal dominant pattern characterized by brownish keratotic papules particularly dense in the seborrheic areas of the body, palmar pits and nail dystrophy .The disease is often exacerbated by sun exposure, perspiration and heat.
Darier's disease. Oral features and genetic aspects.
A variety of skin disorders not actually caused by UVR may sometimes be worsened by it like Darier's disease, transient acantholytic dermatosis (Grover's disease) (3).
Common differential diagnoses of FLP include keratosis pilaris, Darier's disease, follicular mucinosis and lichen scrofulosorum.