Darier's disease


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Related to Darier's disease: lichen planus

keratosis

 [ker″ah-to´sis]
any horny growth, such as a wart or callosity.
actinic keratosis a sharply outlined wartlike or keratotic growth, which may develop into a cutaneous horn, and may become malignant; it usually occurs in the middle aged or elderly and is due to excessive exposure to the sun. Called also senile or solar keratosis. (See Atlas 3, Part F).
keratosis follicula´ris a slowly progressive autosomal dominant disorder of keratinization characterized by pinkish to tan or skin-colored papules on the seborrheic areas of the body that coalesce to form plaques, which may become crusted and secondarily infected; over time, the lesions may become darker and may fuse to form papillomatous and warty malodorous growths. Called also Darier's disease and Darier-White disease.
keratosis palma´ris et planta´ris palmoplantar keratoderma.
keratosis pharyn´gea horny projections from the tonsils and pharyngeal walls. Called also pharyngokeratosis.
keratosis pila´ris hyperkeratosis limited to the hair follicles.
keratosis puncta´ta a hereditary hyperkeratosis in which the lesions are localized in multiple points on the palms and soles.
seborrheic keratosis (keratosis seborrhe´ica) a benign, noninvasive tumor of epidermal origin, marked by numerous yellow or brown, sharply marginated, oval, raised lesions.
senile keratosis (solar keratosis) actinic keratosis.

Darier's disease

Darier's disease

Keratosis follicularis, a rare autosomal dominant skin disease caused by mutations on Chromosome 12. It features warty, foul-smelling plaques formed of coalesced greasy plaques of seborrhoeic dermatitis with severe itching and sometimes pain. The disease is chronic and may worsen with age. Treatment is with oral retinoids. Prenatal diagnosis by DNA analysis of cells obtained by chorionic villus sampling is possible.
Darier's disease; keratosis follicularis progressive autosomal-dominant disorder of keratinization characterized by dark, coalescent, papillomatous/warty epidermal growths
References in periodicals archive ?
Successful treatment of Darier's disease with topical pimecrolimus.
Taking into consideration the characteristic clinical features and positive family history (Fig), a provisional diagnosis of Darier's disease was made.
She had first presented with a psychotic episode at the age of 21 years, and was diagnosed with Darier's disease at the age of 17 years.
Tsambaos, "Reduced expression of the antiapoptotic proteins of Bcl-2 gene family in the lesional epidermis of patients with Darier's disease," Journal of Cutaneous Pathology, vol.
Darier's disease (DD) is a rare congenital acantholytic disorder transmitted as an autosomal dominant trait.
Mutation in the gene ATP2A2 cause Darier's disease.
The histologic findings on skin biopsies of Darier's disease show acantholysis (loss of epidermal adhesion) and dyskeratosis (abnormal keratinization) as the 2 main features.
A clinical and histopathological study of Darier's disease.
Conclusion Cutaneous changes, clinical and histopathological, in Darier's disease are similar to that described in the literature.
CONCLUSION: This case is reported for its uniqueness in conformity with the criteria enunciated by Stulli associated with hyperkeratotic warty papules clinically fitting into Darier's disease.
A variety of skin disorders not actually caused by UVR may sometimes be worsened by it like Darier's disease, transient acantholytic dermatosis (Grover's disease) (3).
Photo aggravated: Herpes simplex, systemic lupus erythematosus, dermatomyositis, pemphigus erythematosus, Darier's disease, erythema multiforme, pityriasis rubra pilaris, psoriasis, lichen planus, lymphocytoma.