A single dose of Quadracel vaccine is approved for use in children four through six years of age as a fifth dose in the diphtheria, tetanus, pertussis vaccination (DTaP) series, and as a fourth or fifth dose in the inactivated poliovirus vaccination (IPV) series, in children who have received four doses of Pentacel and/or DAPTACEL
(Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed), stated the company.
In addition, new data suggest the potential for immunologic interference in the meningococcal human complement serum bactericidal assay (hSBA) responses when MenACWY-D is administered 30 days after Daptacel
(diphtheria and tetanus toxoids and acellular pertussis vaccine [DTaP], Sanofi Pasteur) (16).
The study was funded by Sanofi-Pasteur, maker of Daptacel
One of the reasons for the confusion is that the labeling and packaging are very similar for Adacel (Tdap) and Daptacel
The company has received approval based on data from a pivotal multicentre, randomised, controlled, Phase III trial designed to compare the safety and immunogenicity of Quadracel vaccine with DAPTACEL
and IPOL vaccines in these children who were previously vaccinated with DAPTACEL
and/or Pentacel vaccines.
Adacel[TM] contains reduced amounts of the diphtheria and pertussis components of Daptacel
It has already started to manufacture the DTaP vaccine Daptacel
, and will begin producing Adacel next, she said.
In fact, Aventis Pasteur has already received approval to produce a new DTaP vaccine, Daptacel
, to complement our U.
Additionally, the 2D barcode will include Daptacel
(Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed); Tenivac (Tetanus and Diphtheria Toxoids Adsorbed); IPOL (Poliovirus Vaccine Inactivated) and Pentacel (Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate)) vaccine.
The vaccine, marketed as DAPTACEL
(Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) by Sanofi-Pasteur, was approved for four consecutive doses in 2002, administered at 2, 4, 6, and 15-20 months of age.
From a practical standpoint, this approval allows pediatricians using DAPTACEL
to stock one brand of the vaccine in the refrigerator for use for all five doses, Dr.
The DtaP vaccine Daptacel
, indicated for infants and children, contains somewhat different levels of the three components.