Dalmane


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Related to Dalmane: Halcion

Dalmane

 [dal´mān]
trademark for a preparation of flurazepam hydrochloride, a sedative and hypnotic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

flurazepam hydrochloride

Apo-Flurazepam (CA), Bio-Flurazepam, Dalmane, Novo-Flupam (CA), PMS-Flurazepam (CA), Somnol (CA), Som Pam (CA)

Pharmacologic class: Benzodiazepine

Therapeutic class: Sedative-hypnotic

Controlled substance IV

Pregnancy risk category X

Action

Depresses CNS at limbic, thalamic, and hypothalamic levels by enhancing inhibitory neurotransmitter effect of gamma-aminobutyric acid on neuronal excitability

Availability

Capsules: 15 mg, 30 mg

Indications and dosages

Short-term management of insomnia (less than 4 weeks)

Adults: 15 to 30 mg P.O. at bedtime

Dosage adjustment

• Elderly or debilitated patients

Contraindications

• Hypersensitivity to drug or other benzodiazepines

• Preexisting CNS depression

• Angle-closure glaucoma

• Pregnancy or breastfeeding

Precautions

Use cautiously in:

• hepatic dysfunction

• history of suicide attempt or drug dependence

• elderly patients

• children younger than age 15 (safety not established).

Administration

• Before starting therapy, evaluate patient's mental status and check kidney and liver function tests and CBC.

Adverse reactions

CNS: dizziness, daytime drowsiness, headache, lethargy, confusion, poor concentration, depression, paradoxical excitation, ataxia

EENT: blurred vision

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain

Respiratory: sleep apnea

Skin: rash

Other: abnormal taste, hangover, physical or psychological drug dependence, drug tolerance

Interactions

Drug-drug. Antidepressants, antihistamines, opioids: additive CNS depression

Barbiturates, rifampin: increased flurazepam metabolism, decreased efficacy

Cimetidine, disulfiram, fluoxetine, hormonal contraceptives, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol, valproic acid: decreased flurazepam metabolism, enhanced efficacy

Levodopa: decreased levodopa efficacy

Theophylline: decreased sedative effects of flurazepam

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, total and direct bilirubin: increased levels

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: additive CNS depression

Drug-behaviors. Alcohol use: additive CNS depression

Smoking: increased drug metabolism and clearance

Patient monitoring

• With long-term use, watch for signs and symptoms of physical or psychological dependence.

• Monitor patient's mental status, especially for depression and suicidal ideation.

• Watch for signs of drug hoarding or overuse.

• Monitor CBC and liver and kidney function tests.

Patient teaching

Urge patient (and significant other as appropriate) to report signs and symptoms of depression or suicidal thoughts or actions.

Advise female patient to immediately tell prescriber if she is pregnant. Caution her not to breastfeed.

• Inform patient that drug may cause physical or psychological dependence.

• Advise patient to minimize GI upset by eating frequent, small servings of food and drinking adequate fluids.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Dalmane®

See Flurazepam.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Dalmane

A brand name for FLURAZEPAM.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Marketed under such names as Valium, Klonopin, Xanax, Dalmane, Restoril, and Halcion, these prescription anti-anxiety drugs really do act as sedatives and are very widely prescribed for people suffering from insomnia.
If you are currently taking sleeping pills, tranquilizers or narcotic analgesics (such as Dalmane, Darvon, Valium or codeine), discuss discontinuing these medications with your doctor.
These includes drugs such as diazepam (Valium) and flurazepam (Dalmane).
Charles Mummery, who gave him prescriptions for all kinds of drugs that could leave you too drowsy to do the dishes, let alone fly a plane: the sedatives Valium and Dalmane, and the muscle relaxant Anaprox.
Medications in this group include: lorazepam (Ativan), quazepam (Doral), triazolam (Halcion), flurazepam (Dalmane), estazolam (ProSom) and temazepam (Restoril).
Unfortunately, conventional medicine usually addresses sleep problems with prescription drugs such as benzodiazepines (Clonazepam, Valium, Dalmane, and others), SSRIs (e.g., Paxil), atypical antipsychotic agents (e.g., Seroquel or Zyprexa), or various sleep medications (e.g., Ambien).
Dublin City Coroner's Court heard a third party introduced strychnine into the dalmane - flurazepam - capsules with the intention of harming or injuring an inmate of St Patrick's or to destroy his credibility as the main distributor of drugs.
Getting a fake prescription pad and writing your own medicine wish list could get you a massive haul of drugs including Prozac and heavy duty tranquillisers Xanax and Dalmane.
The FDA announced that the manufacturers of the 13 approved sedative hypnotics, which include older drugs such as Dalmane and newer drugs such as Ambien and Lunesta, had been asked to describe cases of anaphylaxis and angioedema, and cases of complex sleep-related behaviors in their labels.
The label change affects drugs including Zolpidem, marketed as Ambien/Ambien CR by Sanofi-Aventis; butabarbital, marketed as Butisol Sodium by Medpointe Pharmaceuticals HLC; flurazepam, marketed as Dalmane by Valeant Pharmaceuticals; quazepam, marketed as Doral by Questcor Pharmaceuticals; triazolam, marketed as Halcion by Pharmacia & Up-john Inc.; eszopiclone, marketed as Lunesta by Sepracor Inc.; estazolam, marketed as Prosom by Abbott; temazepam, marketed as Restoril by Tyco Healthcare Group; ramelteon, marketed as Rozerem by Takeda Pharmaceutical Inc.; secobarbital, marketed as Seconal by Ranbaxy Pharmaceuticals Inc.; and zaleplon, marketed as Sonata by King Pharmaceuticals Inc.