Treatment of hospitalized patients with complicated gram-positive skin and skin structure infections: Two randomized, multicentre studies of quinupristin/ dalfopristin
versus cefazolin, oxacillin or vancomycin.
Vancomycin, linezolid, gentamicin, moxifloxacin, quinupristin/ dalfopristin
, and rifampicin were 100% effective (susceptible).
Based on the Naranjo probability scale, the likelihood that quinupristin dalfopristin
caused the anemia and reticulocytopenia is probable.
5 mg/kg BID Vancomycin- dalfopristin
resistant enterococci Linezolid 7.
aureus, which were resistant to three or more of the following agents: ciprofloxacin, clindamycin, erythromycin, gentamicin, oxacillin, quinupristin- dalfopristin
, trimethoprim-sulfa, vancomycin, daptomycin, and linezolid.
Available options include vancomycin, linezolid, daptomycin, and quinupristin/ dalfopristin
Although, as a streptogramin B, quinupristin is cross-resistant with macrolides and lincosamides, dalfopristin
is a streptogramin A and not part of this resistance pattern.
It is a novel, injectable antibiotic made of two molecules: quinupristin and dalfopristin
Resistance to erythromycin, clindamycin, tetracycline, and virginiamycin [an analog to quinupristin/ dalfopristin
, which is used to treat vancomycin-resistant Enterococcus faecium infections in humans (Johnson and Livermore 1999)] was investigated.
The product is provided as a 30:70 ratio of quinupristin (pristinamycin I A, a group B streptogramin) and dalfopristin
(pristinamycin II A, a group A streptogramin) (1, 2).
Although all of these linezolid-resistant isolates were still sensitive to the drug combination of quinupristin and dalfopristin
(Synercid), the relatively high prevalence of linezolid resistance is "a cause for concern," said Paul C.
We tested the following: penicillin, amoxicillin, piperacillin, piperacillin and tazobactam, cefotaxime, ceftazidime, ertapenem, imipenem, meropenem, doripenem, gentamicin, tobramycin, amikacin, levofloxacin, ciprofloxacin, moxifloxacin, minocycline, tygecycline, cotrimoxazole, fosfomycin, quinupristin and dalfopristin
, rifampin, daptomycin, linezolid, clindamycin, and fucidic acid.