Teardrop Cell

(redirected from Dacrocyte)
A deformed RBC which is tugged to a nipple at one end, having squeezed through a reticuloendothelial system with increased connective tissue
Aetiology Myelofibrosis, and other reticuloendothelial replacement disorders that compromise the bone marrow space, causing splenic overload or decreased functional splenic tissue—e.g., megaloblastic anaemia, hereditary elliptocytosis, anaemia of renal disease, haemolytic anaemias, sickle cell anaemia, thalassemia, and bone marrow infiltration by haematologic and non-haematologic malignancies may also be accompanied by dacrocytosis. Tear drop cells are also seen in normal peripheral blood smears as an artefact of slide preparation; such dacrocytes are usually easily recognised as their 'tails' all point in the same direction
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

dac·ry·o·cyte

(dak'rē-ō-sīt)
An abnormally shaped red blood cell with a single point or elongation. This form of poikilocyte is associated with myelofibrosis with myeloid metaplasia.
Synonym(s): teardrop cell.
[dacryo- + -cyte]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
3K, the lack of central pallor in combination with the radially symmetrical nature of the cell and lack of sharp cytoplasmic extension of the dacrocyte may reasonably produce a top-3 prediction profile similar to that we see.
(a) Data set Training Validation Test Normal 728 81 203 Echinocyte 226 25 63 Dacrocyte 64 7 18 Schistocyte 546 61 152 Elliptocyte 66 7 18 Acanthocyte 120 13 33 Target cell 523 58 145 Stomatocyte 79 9 22 Spherocyte 173 19 48 Overlap 166 18 46 (a) Cells were randomly distributed 80:20 between training and test sets, respectively.
The 10 class labels chosen were based on clinical significance and availability: schistocytes, dacrocytes (teardrop cells), acanthocytes, elliptocytes, stomatocytes, spherocytes, codocytes (target cells), echinocytes, overlap, and normal.
The highest rate of misclassification occurred with dacrocytes and acanthocytes, both of which were predominantly misclassified as schistocytes (Table 2).
Dacrocytes demonstrated the lowest recall (61%) and the lowest precision (85%).
Teardrop cells (dacrocytes) are associated with an abnormal spleen or bone marrow as in primary myelofibrosis, where the red cells must stretch out in order to navigate its way into the periphery (Figure 2 Slide C).
Pencil cells Iron deficiency Stomatocytes Artifact (due to slow drying in humid environment), Liver disease, alcoholism, Rh-null disease, Obstructive lung disease Elliptocytes Hereditary Elliptocytosis (>25%) Bite cells (degmacytes) G6PD deficiency, Oxidative stress, unstable haemoglobins, congenital heinz body anaemia Basket cells (half ghost Oxidant damage, G6PD deficiency, cells/Blister cells) Unstable haemoglobins Spherocytes Hereditary spherocytosis, ABO incompatibility, Autoimmune hemolytic anemia (warm antibody type), Severe burns Teardrop red cell Idiopathic myelofibrosis, (dacrocytes, myelophthisic anaemia, lacrymocytes) thalassemias