Mutations in the related DVL1 and DVL3
genes are known to cause Robinow syndrome, a rare inherited disorder in humans characterized by strikingly similar anatomical changes--a short, wide "babyface," short limbs, and spinal deformities.
Caption: Figure 1: Characteristic immunohistochemical staining of DVL3 and sFRP3 expression levels.
Pecina-Slaus, "Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin," International Journal of Molecular Sciences, vol.
Gabud, Ekspresijaproteina sFRP3 i DVL3, kljucnih molekula signalnogputa Wnt u glioblastomu, [M.S.
In 56% of cases with cytoplasmic expression, the protein was located in close proximity to the cell membrane which can be explained with the known fact that DVL3 can be engaged in the membranous complex pulling out AXIN from the beta-catenin destruction complex, thus preventing beta-catenin's degradation and elevating its cytosolic levels.
It opens doors for future mechanistic investigations on DVL3 and sFRP3 roles in glioblastoma.
Increased expression of DVL3 protein could result in strengthening its transcriptional activity and consequently stimulating activity of Wnt signaling.
The present study investigated the involvement of two Wnt signaling pathway proteins, DVL3 and sFRP3, in glioblastoma and demonstrated for the first time their expression levels and relationships.
According to Professor Henry Ho at the UC Davis School of Medicine who studies similar genes in humans, mutation in the related DVL1 and DVL3
genes are known to cause Robinow syndrome, a rare inherited disorder in humans characterised by strikingly similar anatomical changes.
[sup] In addition, SOX2 affects the protein expression levels of DKK3, DVL1 and DVL3
, which are regulators or downstream molecules of Wnt signaling.
miRNA Target Partial target genes numbers miR-2070-3p 1352 SH3D21, BCL7C, ACTR3B, EPC1 miR-222 624 RGS6, HMG20A, RBM15, NFE2 miR-502-3p 462 CRTC1, FGD1, CCL8, STARD8 miR-6238 391 Mcph1, PDZK1 miR-7446-3p 414 KLF13, SIAH2, TUB miR-7475-5p 517 LDB1, DVL3
, PEG3, LRP1, LATS2, EFHD2 miR-125a-5p 2246 ESRRa, SENP2, BCL2L12, SREBP-1, ABCA2, NNMT miR-126 2438 TNKS2, PTPRU, RGS14, NAP1L5 miR-378e 1044 IGF1R, CACNB2, RASIP1, API5, SCD5, SLC25A29 miR-7930-3p 1793 CABIN1, PCDHA2, PLXNA4
Tres miembros de la familia Dishevelled (Dsh) (Dvl1, Dvl2 y Dvl3
) se han identificado en humanos .