DUSP9

A gene on chromosome Xq28 that encodes dual-specificity phosphatase 9, a protein which downregulates MAP kinases of the ERK family. It is expressed in the placenta, kidneys and foetal liver.

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Other genetic loci associated with type 2 diabetes are ZBED3 (Zinc finger, BED type containing), TP53INP1 (Tumor protein p53 nuclear protein also known as stress inducible protein), CHCHD9 (Coiled-coil-helix-coiled coil-helix domain containing 9), CENTD2 (Arf-GAP with Rho-GAP domain, ANK repeat and PH domain containing protein 1), KCNQ1 (Potassium voltage gated channel subfamily KQT member 1), HMGA2 (High mobility group AT hook 2), HNF1A (Hepatocyte nuclear factor 1 home box A), PRC1 (Protein regulator of cytokinesis 1), ZFAND6 (Zinc finger, AN-1 type domain), DUSP9 (Dual specificity phosphatase 9).

Genetic factors in the etiology of type 2 diabetes: linkage analyses, candidate gene association, and genome-wide association--still a long way to go!

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