DUSP9

A gene on chromosome Xq28 that encodes dual-specificity phosphatase 9, a protein which downregulates MAP kinases of the ERK family. It is expressed in the placenta, kidneys and foetal liver.

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We did not detect mRNA of the atypical MKPs DUSP13, DUSP15, DUSP26, and DUSP27, the classical MKP DUSP9, the tensin homolog TPTE, the eyes absent EYA1, EYA2, and EYA4, and the myotubularin MTMR7.

Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function

Other genetic loci associated with type 2 diabetes are ZBED3 (Zinc finger, BED type containing), TP53INP1 (Tumor protein p53 nuclear protein also known as stress inducible protein), CHCHD9 (Coiled-coil-helix-coiled coil-helix domain containing 9), CENTD2 (Arf-GAP with Rho-GAP domain, ANK repeat and PH domain containing protein 1), KCNQ1 (Potassium voltage gated channel subfamily KQT member 1), HMGA2 (High mobility group AT hook 2), HNF1A (Hepatocyte nuclear factor 1 home box A), PRC1 (Protein regulator of cytokinesis 1), ZFAND6 (Zinc finger, AN-1 type domain), DUSP9 (Dual specificity phosphatase 9).

Genetic factors in the etiology of type 2 diabetes: linkage analyses, candidate gene association, and genome-wide association--still a long way to go!

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