DUSP3

DUSP3

A gene on chromosome 17q21 that encodes dual-specificity phosphatase 3, a protein which dephosphorylates and inactivates ERK1/MAPK3 and ERK2/MAPK1.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
In addition, it has been demonstrated that ROS generated by commensal bacteria inactivated dual-specific phosphatase 3 (DUSP3) by oxidation on Cys-124 results in ERK activation [58].
Asiaticoside is known to induce a dual specificity protein phosphatase (DUSP) and dual specificity phosphatase 3 (DUSP3) that negatively regulate the mitogen-activated protein (MAP) kinase superfamily, and the associated cellular proliferation and differentiation, in normal human dermal fibroblasts (Lu et al.