DUSP3 | definition of DUSP3 by Medical dictionary
DUSP3 A gene on chromosome 17q21 that encodes dual-specificity phosphatase 3, a protein which dephosphorylates and inactivates ERK1/MAPK3 and ERK2/MAPK1.
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References in periodicals archive
In addition, it has been demonstrated that ROS generated by commensal bacteria inactivated dual-specific phosphatase 3 (DUSP3
) by oxidation on Cys-124 results in ERK activation .
Asiaticoside is known to induce a dual specificity protein phosphatase (DUSP) and dual specificity phosphatase 3 (DUSP3
) that negatively regulate the mitogen-activated protein (MAP) kinase superfamily, and the associated cellular proliferation and differentiation, in normal human dermal fibroblasts (Lu et al.