DUSP3

A gene on chromosome 17q21 that encodes dual-specificity phosphatase 3, a protein which dephosphorylates and inactivates ERK1/MAPK3 and ERK2/MAPK1.

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In addition, it has been demonstrated that ROS generated by commensal bacteria inactivated dual-specific phosphatase 3 (DUSP3) by oxidation on Cys-124 results in ERK activation [58].

ROS and ROS-Mediated Cellular Signaling

Asiaticoside is known to induce a dual specificity protein phosphatase (DUSP) and dual specificity phosphatase 3 (DUSP3) that negatively regulate the mitogen-activated protein (MAP) kinase superfamily, and the associated cellular proliferation and differentiation, in normal human dermal fibroblasts (Lu et al.

Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

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