DUSP22

DUSP22

A gene on chromosome 6p25.3 that encodes dual-specificity phosphatase 22, which upregulates the JNK signalling pathway and downregulates p38 and stress-activated protein kinase/c-Jun N-terminal kinase.
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References in periodicals archive ?
Chromosomal rearrangement of DUSP22 is present in about 30% of ALK--anaplastic large cell lymphomas, and these cases have a much better prognosis than other ALK-anaplastic large cell lymphomas, particularly those with TP63 rearrangement.
The JNK- and ERK-specific DUSP22 and DUSP23 were found upregulated in our analysis, suggesting an important role in controlling intracellular signalling during Th1 polarisation or effector function.