DUSP2

DUSP2

A gene on chromosome 2q11 that encodes dual-specificity phosphatase 2, a protein which regulates mitogenic signal transduction by dephosphorylating Thr and Tyr residues on MAP kinases ERK1/MAPK3 and ERK2/MAPK1. It is expressed in haematopoietic tissues.
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References in periodicals archive ?
In particular, three clusters (CL1, CL5, and CL6) showed a statistically significant enrichment in "T cell-related" gene categories and included several genes typically associated with T cell-mediated immune responses such as: CD3E, CD4, CD6, CD28, CTLA4, and DUSP2.
These genes includes AKAP13, AMER2, BBX, CEP97, CYP46A1, DPP3, DUSP2, GLIS3, GNB2, KLHL31, KMT2E, L1CAM, MINK1, NLN, PCSK5, PFKFB3, PHF6, PRPF38B, RB1, RGS7BP, RSF1, SEMA4C, SLC35F3, SLITRK2, SNX17, TNKS1BP1, TNPO1, and ZBTB41.
Term Count P value Genes MAPK signaling pathway 13 0.0062 RPS6KA5, AKT1, MAP4K4, MAP3K5, PLA2G4A, DUSP2, FGF9, TGFBR1, MAP2K4, MKNK2, PPP3R1, FGF12, DUSP6 Endocytosis 10 0.010 IGF1R, ADRB3, FLT1, TGFBR1, PSD3, VPS4B, DNAJC6, PSD2, ARAP2, LDLRAP1 Axon guidance 7 0.042 EPHA5, SEMA6A, PLXNA1, PPP3R1, SEMA4C, L1CAM, SRGAP1 Insulin signaling 6 0.0076 AKT1, L1CAM, IGF1R, IRS2, pathway SOCS7, RHOQ Focal adhesion 4 0.021 VCAM1, L1CAM, ITGA4, CERCAM Table 2: Small molecules which might reverse the dysregulation of AD in EC and HIP regions.
Given the versatile roles of transferases, differential methylation of this group of genes (including HEXIM1, SFN, CBLC, and DUSP2) may influence a wide range of cellular processes in a way that interferes with timely onset of labor and parturition.
Moreover, many of such genes played a role in B cell response, like EGR1 (CL1), or in T cell response like, for example, CTLA4, CD4, and MLL (CL1); DUSP2 (CL3); and CD28 (CL4) and NR4A2 (CL5).
Gene Microarray Q-PCR PLK2 2.2 [+ or -] 0.1 1.8 [+ or -] 0.4 SGK 3.9 [+ or -] 0.2 3.4 [+ or -] 1.5 SE20-4 2.5 [+ or -] 0.2 2.4 [+ or -] 0.2 BHLHB2 2.8 [+ or -] 0.1 4.2 [+ or -] 0.2 CCNL1 3.1 [+ or -] 0.2 2.6 [+ or -] 0.4 C8FW 4.0 [+ or -] 0.2 2.3 [+ or -] 0.2 HES1 8.9 [+ or -] 0.9 1.7 [+ or -] 0.4 FOSB 52 [+ or -] 1.8 2.6 [+ or -] 0.1 DUSP2 17 [+ or -] 0.0 1.7 [+ or -] 0.1 PPP1R15A 4.6 [+ or -] 0.1 0.9 [+ or -] 0.2 NFKB1A 3.7 [+ or -] 0.3 0.9 [+ or -] 0.2 NEU1 2.2 [+ or -] 0.1 1.1 [+ or -] 0.1 DDAH1 -2.2 [+ or -] 0.0 -1.8 [+ or -] 0.1 NFATC1 -2.9 [+ or -] 0.0 -1.8 [+ or -] 0.2 NVKB1 -2.8 [+ or -] 0.0 -5.2 [+ or -] 0.8 Data are mean [+ or -] SD of three independent measurements, which represent fold change on [log.sub.2] scale compared with data obtained from control group.
Among the 9 out of 10 classical MKPs [8] whose expression was detected, DUSP1, DUSP2, DUSP4, DUSP7, and DUSP16 were found in the group of highly expressed PTPs (Figure 2).
Interestingly, it has been proposed that the spatial distribution of dephosphorylated MAPKs is regulated by the binding of MKPs, such as the nucleocytoplasmic location of ERK by nuclear DUSP5 and cytoplasmic DUSP6, and the accumulation of ERK in the nucleus by DUSP2, DUSP4, and DUSP5 [64-66].