DUSP12

DUSP12

A gene on chromosome 1q21-q22 that encodes dual-specificity phosphatase 12, a ubiquitous enzymes that downregulates members of the MAP kinase superfamily (e.g., MAPK/ERK, SAPK/JNK and p38 MAP kinases). It is highly expressed in the spleen, testes, ovaries and peripheral leukocytes.
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The Genome-wide Association Study demonstrated that genetic variations in the CASC15 , BARD1 , LMO1 , DUSP12 , HSD17B12 , HACE1 , and LIN28B genes are associated with NB risk in North American patients of European descent.[5],[6],[7],[8],[9]
The most significant 10 DEGs were HOXB7 (FDR=1.69E-07), SMYD3 (FDR=2.36E-07), ECT2 (FDR=3.19E-07), CBX3 (FDR=4.69E-07), AURKA (FDR= 7.46E-07), WDHD1 (FDR=9.01E-07), MTHFD2 (FDR=2.87E-06), KIF4A (FDR=5.72E-06), DUSP12 (FDR=5.94E-06), and FNDC3B (FDR=6.18E-06).