DUSP10

DUSP10

A gene on chromosome 1q41 that encodes dual-specificity phosphatase 10, a protein which inactivates MAP kinases MAPK11, MAPK12, MAPK13 and MAPK14.
References in periodicals archive ?
Among the dysregulated genes, the top 12 genes from All Sources, Blood Source, Lymphocyte Source, and Monocyte Source were CDC37, NCOA2, P2RY12, RXRB, EDEM2, ACTN4, STX12, PPM1A, PRKACB, DUSP10, VEGFA, and SLC44A2.
Huang et al., "The NLR adaptor ASC/PYCARD regulates DUSP10, mitogenactivated protein kinase (MAPK), and chemokine induction independent of the inflammasome," Journal of Biological Chemistry, vol.
DUSP5, DUSP6, DUSP8, and DUSP10 were found inside the group of middle expressed PTPs.
Genes encoding proteins related to immune pathway (DUSP10), cell signaling (PLA2G4A, PRKCD), epigenetic regulation (DNMT3L, H2AFZ, MBD3), cell differentiation (LIF), cell adhesion and signal transduction (ITGAV), metabolic pathway (RASL 12), and cell apoptosis (FAS) were differentially expressed among the three groups, consistent with the results determined using RNA-Seq.
(a) DUSP10: Dual specificity phosphatase 10, immune pathway-related gene.
DUSP10 (also known as MKP-5) as DUSP1 refers to the family of phosphatases that regulate the activity of mitogen-activated protein kinases.
Tze-Han Huang et al., "The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome," Journal of Biological Chemistry, vol.