DUSP1

DUSP1

A gene on chromosome 5q34 that encodes dual-specificity phosphatase 1, a protein which dephosphorylates MAP kinase MAPK1/ERK2. DUSP1 downregulates cell proliferation and is thought to play a key role in cellular responses to environmental stress. It is also a less preferred gene symbol for what is now designated as DUSP12, see there.
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Eighty-eight transcription regulators were found in the adipose tissue between 18 vs 24, KLF5, one of activated transcription regulators, which is relevant to cancer, cellular development, cellular growth and proliferation, and this regulator is unregulated FAM110A, MYC, DUSP1, ACTA2, NOTCH1 and PREB, down regulated RUNX1 (Fig.
Inactivation of MAPKs by dual-specificity phosphatase 1 (DUSP1), also called mitogen-activated protein kinase phosphatase (MKP-1), was recently shown to be increased in circulating blood cells of CVD patients even after treatment with conventional drugs, such as statins [6].
Glucocorticoids can induce the expression of a dual specificity phosphatase 1 (DUSP1), also known as MAPK phosphatase 1 (MKP-1) [60, 61, 72-74].
miR-567 SPTBN1; DUSP1; BCHE; LPHN2 miR-141-3p H3F3B; TCEAL2; MYH10; LHFP; LPHN2; CCL2; KLF9 miR-454-3p DPYSL2; HOXA5; FKBP11; SRPX; EDN1; LDLR; CAV2; BMPR2; SLC2A1 SERPINE2; PLEKHC1; SPTBN1; H3F3B; miR-590-3p TMEM47; TIMP3; COL3A1; CXCL13; ETS2; CELSR3; LPL; SMAD6; BMPR2; LPHN2; SASH1.
At 250 and 500 [mu]A, this pathway was regulated by IL-10 and DUSP1, and IL-1 [beta] was not significantly upregulated from the sham group.
Twenty-two genotypes affecting copper concentrations were determined as MCL1, DDX28, MRPS26, RPUSD2, DDIT3, PELO, SLC30A1, C20orf111, SOCS3, SOX9, DNAJB4, NXF1, MAF1, MAFG, AMOTL2, ADM, ZFAND2A, ZFAND5, DUSP1, TBCC, HPS6, and INTS5.
Other five genes, DUSP1, EPHX2, NUDT1, RNF7, and SEPP1, demonstrated a statistically significant modulation in poor prognosis patients in three out of six tumor types (Figure 3 and Suppl.
Among the genes being most important for the regulation of MAPK cascade and the level of expression that was activated during RIL suppression, DUSP1 was also identified.
Esta clase de genes incluye: la proteina fosfatasa dual especifica 1 (DUSP1), la proteina quinasa activada por mitogenos fosfatasa1 (MAPK-1), el gen antiinflamatorio interleucina-10 (IL-10), la citoquina antiinflamatoria inducida por GC, con motivo estructural de cremallera de leucina (GILZ), una proteina de interaccion de NF[kappa]B la cual inhibe la funcion de NF[kappa]B y AP-1, un fosfolipido-dependiente de calcio (Anexina-1).
In contrast, at day 15 after enucleation expression of only 2 genes was upregulated (Anxa1 and podoplanin--Pdpn) and expression of 7 genes was downregulated, including genes of myelocytomatosis oncogene (Myc); Bmp2; transcription factors Prox1 and Hhex; dual specificity phosphatase 1 (Dusp1); signal transducer and activator of transcription 5B (Stat5b) and protein Prdm.