dTMP


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dTMP

Farlex Partner Medical Dictionary © Farlex 2012

dTMP

Abbreviation for deoxythymidylic acid.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
TS catalyzes the conversion of dUMP into dTMP using 5,10-MTHF.
On the one hand, it can have a protective effect because it leads to an increase in the supply of 5,10-MTHF, which can serve as a substrate in the conversion of dUMP to dTMP This would reduce misincorporation of dUMP into DNA, preventing DNA double-strand breaks and chromosomal instability.
Thymidylate synthase (TS) is a 36-kDa dimeric protein that catalyzes methylation of deoxyuridine monophosphate (BUMP) to deoxythymidine monophosphate (dTMP), using the reduced folate 5,10-methylenetetrahydrofolate as the methyl donor (53, 54).
The mean background (determined from quadruplicate blanks) was subtracted from each reaction, and the total dTMP incorporation into high-molecular weight products (radioactive and nonradioactive) was calculated.