DST


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DST

A gene on chromosome 6p12.1 that encodes dystonin, a cytoskeletal linker protein which integrates intermediate filaments, actin and the microtubule cytoskeleton network, and is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional reticulum.

DST isoform 3 plays a structural role in assembling hemidesmosomes of epithelial cells; it anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes and is required for regulating keratinocyte polarity and motility; it mediates integrin ITGB4 regulation of RAC1 activity. DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport.

Molecular pathology
Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
References in periodicals archive ?
After graduating from his physics/electronic and telecommunications engineering double degree, Doughney scored a highly sought after place in DSTs graduate program.
However, Sandoval noted that it increased the effective rate for preneed plans to 0.20 percent from 0.10 percent, and also doubled the DST for certificates of damages.
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DST has become a means for the private investor to build and preserve wealth within a regulated investment environment using institutional-grade real estate on a tax-deferred basis while enjoying tax sheltered passive income.
Whether a DST would be creditable under a double tax convention is another concern.
The provisions abovementioned are crystal clear on what forms the basis of the CGT and DST. The only basis for the computation are either the gross selling price or the fair market value, whichever is higher.
BofA Merrill Lynch acted as financial advisor and Skadden, Arps, Slate, Meagher and Flom acted as legal advisor to DST.
According to Stone, the combination of SS&C and DST will "position us to capitalize on the demand for outsourcing in financial services and better enable our clients to address increasing competitive and regulatory pressures."
Practical exercises were executed at multiple locations across Fort Benning to simulate a variety of environments that might be experienced by DST members.
However, there are some who are against DST, arguing that it raises safety concerns including that people may have to leave their homes early in the morning when it is still dark.
The switch to DST was introduced in several countries following the oil shock of 1973 in order to save energy by reducing lighting needs in the late afternoon.
The Defence Science and Technology (DST) Group is part of Australia's Department of Defence.