DSPP


Also found in: Dictionary, Legal, Acronyms, Encyclopedia.

DSPP

A gene on chromosome 4q21.3 that encodes one of the two main proteins of the dentin extracellular matrix, which is secreted as a preproprotein by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be
involved in the biomineralisation process of dentin.

Molecular pathology
DSPP mutations are associated with dentinogenesis imperfecta-1, which in some patients is combined with autosomal dominant form of deafness.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
DSPP and DMP-1 have been suggested to be the main phenotypic markers of odontoblasts [7].
Genes Sequence Size (bp) Forward: 5 '-ACCCGCTGTCTTCTAGCGT-3' BMP2 Reverse: 5'-TTTCAGGCCGAACATGCTGAG-3' 180 Forward: 5,-CCTCCTGGTATCTCAACCACA-3' Foxc2 Reverse: 5'-GAGGGTCGAGTTCTCAATCCC-3' 134 Forward: 5'-CTATCCTGGCTCCGTGCTC-3' ALP Reverse: 5,-GCTGGCAGTGGTCAGATGTT-3' 100 Forward: 5'-CTCACACTCCTCGCCCTATT-3' OCN Reverse: 5'-TTGGACACAAAGGCTGCAC-3' 107 Forward: 5'-GCCACTTTCAGTCTTCAAAGAGA-3' DSPP Reverse: 5'-GCCCAAATGCAAAAATATGTAA-3' 130 Forward: 5,-AAAATTCTTTGTGAACTACGGAGG-3' DMP1 Reverse: 5'-GAGCACAGGATAATCCCCAA-3' 94 Forward: 5'-AAGGTGAAGGTCGGAGTCAA-3' GAPDH Reverse: 5'-AATGAAGGGGTCATTGATGG-3' 108
Shares for a DSPP can come from a new issue, from those held in treasury, perhaps from a buyback, or through open market purchases.
The mRNA expression levels of DSPP, DMP-1, Runx2, and OCN were determined using qRT-PCR.
Interestingly, the expression level of dentin-specific marker DSPP was highly detected in DDM/hDPSCs transplant, but not in HA-TCP/hDPSCs transplant (Figure 7(e)), indicating that DDM might have a better effect on dentin regeneration than HA-TCP.
Further, the late-stage gene expression analysis in Figure 7 revealed that Npnt tended to direct the hDPSCs' differentiation toward osteoblastic lineage instead of odontoblastic lineage, as the DSPP, a well-established odontoblast differentiation marker [27], was moderately suppressed by Npnt, but BSP, a widely recognized osteoblast marker, [28] was markedly enhanced by Npnt compared to the other groups.
DSPP primers were sense, 5'-GCATTTGGGCAGTAGCATGG-3'; and antisense, 5'-CTGACACATTTGATCTTGCTAGGAG-3'.
Kim, "Functional splicing assay of DSPP mutations in hereditary dentin defects," Oral Diseases, vol.
Odontoblasts secrete several collagenous and noncollagenous proteins, such as type I collagen, osteopontin, dentin matrix protein 1 (DMP1), and dentin sialophosphoprotein (DSPP), which are special biological markers for the odontoblast/osteoblast-like differentiation of DPCs [15, 16].