DSG3


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DSG3

A gene on chromosome 18q12.1 that encodes desmoglein 3, a component of intercellular desmosome junctions, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell–cell adhesion. It is expressed in the epidermis, tongue, tonsil and oesophagus.

Molecular pathology
Desmoglein 3 is the antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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Although the function of Dsg1 that is expressed in all the layers of the mucosa is impaired by these antibodies, coexisting Dsg3, when expressed at a higher level than Dsg1, can compensate for the loss of Dsg1 function.
When only anti-Dsg 3 Abs are found in serum (i.e., mucosal-dominant pemphigus vulgaris), the function of Dsg3 that is interfered with in the epidermis can be compensated for by Dsg1 that is expressed throughout the epidermis.
However, the subclasses differentiated by the target antigens (i.e., Dsg1 and Dsg3) were not always identical to the clinical phenotypes for 45% (5/11) of our patients.
Disease activity is associated with Dsg1 and Dsg3 antibody titers.
Anti-Desmoglein 3 (Dsg3) antibody (catalog # 603-810) has been validated for use in Western blot, and immunohistochemistry on paraffin-embedded human sections.