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DSG3A gene on chromosome 18q12.1 that encodes desmoglein 3, a component of intercellular desmosome junctions, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell–cell adhesion. It is expressed in the epidermis, tongue, tonsil and oesophagus.
Desmoglein 3 is the antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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