DSG2

DSG2

A gene on chromosome 18q12.1 that encodes desmoglein 2, a calcium-binding transmembrane glycoprotein component of desmosomes expressed in the colon, in colorectal carcinoma, and in other simple and stratified epithelial-derived cell lines.

Molecular pathology
Defects in DSG2 cause arrhythmogenic right ventricular dysplasia, type 10, and susceptibility to cardiomyopathy dilated type 1BB.
References in periodicals archive ?
5% muscle 1 DCM TTN Titin 13%-27% MYH7 Myosin, heavy chain 7 [congruent to] 5% LMNA Lamin A/C [congruent to] 5% DSP Desmoplakin [congruent to] 5% TNNT2 Troponin T2, cardiac type 2%-3% TPM1 Tropomyosin 1 (alpha) [congruent to] 2% TNNI3 Troponin I3, cardiac type <1% BAG3 BCL2 associated athanogene 3 N/A (a) RBM20 RNA binding motif protein 20 N/A ARVC PKP2 Plakophilin 2 25%-30% DSP Desmoplakin 9% DSG2 Desmoglein 2 3.
Among the gene variants identified in the study as associated with SIC are MYLK2, DSG2, FKTN, and LDB3.
This pair was driven by a Farnell stabilized power supply E30/2 coupled to a Farnell synthesized digital signal generator DSG2 whose outputs were fed through a Hewlett-Packard 6826A bipolar power supply/amplifier acting as a variable gain amplifier.