Upregulation of six genes (ABCA7, ApoE, CASS4, CELF1, PTK2B, and ZCWPW1) and downregulation of one gene (DSG2
) were noted and indicate that PPAR[gamma] agonists may represent an attractive class of drugs for preventing or delaying the onset of late onset AD .
Most variants associated with ARVC occur in genes encoding desmosomal proteins [plakophilin 2 (PKP2), desmocollin 2 (DSC2), desmoglein 2 (DSG2
), desmoplakin (DSP), junction plakoglobin (JUP)] (9).
(c-e) Formation of intercalated disk structures in beating spheres after 10 days of CEDPs differentiation, shown by double-IF-staining with anti- cTnT/anti-Desmoplakin (DSP), anti-cTnT/anti-Desmocollin-2 (DSG2
), and anti-MyHC/anti-Desmoplakin.
Among the gene variants identified in the study as associated with SIC are MYLK2, DSG2
, FKTN, and LDB3.
HAdV-B3 is a representative of the species B types that utilize CD46 and/or desmoglein 2 (DSG2
) as attachment receptors [39,43,44].
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2
, Dsg3, and Dsg4.
mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy.
These genes encode components of desmosomes (DSG2
), gap junctions (CX26), tight junctions (CLDN4, CLDN7), the cornified envelope (SPRRIA, 2A, 2B, 2E, 2F, 2G, 2I, 2J), intermediate filaments (KRT19), and a variety of cell-surface and extracellular-matrix glycoproteins (SPP1, BGP1, BGP2, MUC1, TROP2, CLU).