DSG2

DSG2

A gene on chromosome 18q12.1 that encodes desmoglein 2, a calcium-binding transmembrane glycoprotein component of desmosomes expressed in the colon, in colorectal carcinoma, and in other simple and stratified epithelial-derived cell lines.

Molecular pathology
Defects in DSG2 cause arrhythmogenic right ventricular dysplasia, type 10, and susceptibility to cardiomyopathy dilated type 1BB.
References in periodicals archive ?
Upregulation of six genes (ABCA7, ApoE, CASS4, CELF1, PTK2B, and ZCWPW1) and downregulation of one gene (DSG2) were noted and indicate that PPAR[gamma] agonists may represent an attractive class of drugs for preventing or delaying the onset of late onset AD [73].
Most variants associated with ARVC occur in genes encoding desmosomal proteins [plakophilin 2 (PKP2), desmocollin 2 (DSC2), desmoglein 2 (DSG2), desmoplakin (DSP), junction plakoglobin (JUP)] (9).
(c-e) Formation of intercalated disk structures in beating spheres after 10 days of CEDPs differentiation, shown by double-IF-staining with anti- cTnT/anti-Desmoplakin (DSP), anti-cTnT/anti-Desmocollin-2 (DSG2), and anti-MyHC/anti-Desmoplakin.
Among the gene variants identified in the study as associated with SIC are MYLK2, DSG2, FKTN, and LDB3.
HAdV-B3 is a representative of the species B types that utilize CD46 and/or desmoglein 2 (DSG2) as attachment receptors [39,43,44].
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
These genes encode components of desmosomes (DSG2), gap junctions (CX26), tight junctions (CLDN4, CLDN7), the cornified envelope (SPRRIA, 2A, 2B, 2E, 2F, 2G, 2I, 2J), intermediate filaments (KRT19), and a variety of cell-surface and extracellular-matrix glycoproteins (SPP1, BGP1, BGP2, MUC1, TROP2, CLU).