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A gene on chromosome 1p36.1-p35 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB2 functions in axon guidance during development, guiding commissural axons and forming a major interhemispheric connection between the two temporal lobes of the cerebral cortex. EPHB2 is also involved in the guidance of contralateral inner ear efferent growth cones at the midline, and of retinal ganglion cell axons to the optic disk. It also regulates dendritic spines development and maturation, and it stimulates the formation of excitatory synapses.

Activation of EPHB2 by EFNB1 abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. EPHB2 also controls other aspects of development, including angiogenesis, palate development, as well as inner ear development by regulating endolymph production. It may act as a tumour suppressor.

Molecular pathology
Defects in EPHB2 have been linked to prostate cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Dead right there Medtalk A macabre adjective referring to a Pt who has been clinical kaputt long enough to minimize the likelihood of resuscitation
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
DRT police received a call from a concerned citizen informing that the policewoman committed suicide.
The DRT facilitates the recovery of debt involving banks and other financial institutions with their customers.
The Public Transport Service was said to have now brought in measures such as ticket machines with GPS tracking capability for all DRT operators.
The declaration speaks in behalf of the people of DRT, that they are ready to embrace the lasting peace for sustainable development in the years to come," Valdez said.
"Smart city initiatives, new mobility policies, government mandates, and reduced private ownership of cars will result in DRT accounting for approximately 50 per cent of the shared mobility market by 2030," said Ankita Mukherji, Mobility Research Analyst at Frost & Sullivan.
said the DOT decided to facilitate B2B meetings between local and international stakeholders during the DRT Show Philippines to take advantage of the expo's huge attendance of prospective markets.
The DRT was calculated by subtracting the resected lateral condyle thickness from the resected medial condyle thickness.
A Google search also turned up no stories that connect Hamlett to the DRT data breach.
(8) The DRT, unlike the skin, is acellular and therefore does not require immediate revascularization for successful incorporation into poorly vascularized tissues such as bare bone.
The moment power trips, the court room is completely dark and the documents cannot even be read," said Vivek Kumar Singh, President, DRT Bar Association.
The DRT shortly thereafter sued the land office over the library, saying Bush was attempting an "unconstitutional taking" of private property.
DirtNap's new DRT HD broadhead is available in 150--and 175-graln configurations.