DRD5

DRD5

A gene on chromosome 4p16.1 that encodes G protein-coupled dopamine receptor D5, which stimulates adenylyl cyclase. D5 receptor is expressed in neurons in the limbic regions of the brain, and it has a 10-fold greater affinity for dopamine than D1 receptor.

Molecular pathology
Defects in DRD5 cause benign essential blepharospasm.
References in periodicals archive ?
Significant associations have been shown between DAT-1, DRD4, DRD5, 5HTT, HTR1B and SNAP-25 genes and the ADHD.
De acuerdo con las multiples alteraciones que presenta el TDAH se podria mencionar que es heterogeneo, ya que se pone de manifiesto desde las causas que lo originan (geneticas, ambientales) y la implicacion de multiples genes (ADRA2A, SLC6A2, DRD4, DRD5, DAT), en la variedad de expresion de los sintomas (inatencion, hiperactividad, impulsividad) y la comorbilidad con otros trastornos neuropsiquiatricos (trastornos de conducta, trastornos de aprendizaje, ansiedad, depresion) (Lopez et al.
Furthermore, their team was the first to report a significant association between nicotine dependence and genetic variants in DRD5, MAP3K4 and NPY1R.
DRD1 and DRD5 activate adenylyl cyclase and increase cAMP production.
that specific genotypes of DRD4 and DRD5 are associated with increased risk of ADHD [36].
Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci.
Asherson 2000 Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children.
Antisociality, substance dependence, and the DRD5 gene: A preliminary study.
The D1-like family receptors include the DRD1 and DRD5 genes.
After 2005 studies in China increasingly focused on the genes encoding DRD1, DRD5, and DA transporter 1 (DAT1).