DRD4


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DRD4

A gene on chromosome 11p15.5 that encodes a G protein-coupled dopamine receptor responsible for neuronal signalling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behaviour. Soft data suggest that DRD4 may play a role in novelty-seeking behaviour.
References in periodicals archive ?
Smolen, "The DRD4 VNTR polymorphism influences reactivity to smoking cues," Journal of Abnormal Psychology, vol.
The genotyping of DRD4 exon III was carried out by polymerase chain reaction with the following primer sequences:
No Association between the Response to Methylphenidate and DRD4 Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder: A Case Control Study.
DRD4 is one of several genes that determines the way dopamine -- a crucial neurotransmitter, or chemical messenger -- is released in the brain.
The effect of the OPRM1 and DRD4 polymorphisms on the relation between attentional bias and alcohol use in adolescence and young adulthood.
The genes are the dopamine transporter 1 (DAT1) gene, the three D2-like dopamine receptor (DRD2, DRD3, and DRD4) genes and the monoamine oxidase-A gene.
De acuerdo con las multiples alteraciones que presenta el TDAH se podria mencionar que es heterogeneo, ya que se pone de manifiesto desde las causas que lo originan (geneticas, ambientales) y la implicacion de multiples genes (ADRA2A, SLC6A2, DRD4, DRD5, DAT), en la variedad de expresion de los sintomas (inatencion, hiperactividad, impulsividad) y la comorbilidad con otros trastornos neuropsiquiatricos (trastornos de conducta, trastornos de aprendizaje, ansiedad, depresion) (Lopez et al., 2010, pp.
Reward circuitry responsivity predicts future increases in body mass: Moderating effects of DRD2 and DRD4. Neuroimage, 50, 1618-1625.
Linking gene, brain, and behavior: DRD4, Frontal asymmetry, and temperament.
[30] Zhao and colleagues did not find an association between DRD4 and ADHD, but did find that DRD4 was associated with the internalizing behaviors of ADHD.
Returning to her lab, she focussed on a tiny section of DRD4 genes and found that skiers and riders with a particular variant of DNA were much more likely to score high on the tests of risk-taking.