DRD3


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DRD3

A gene on chromosome 3q13.3 that encodes G protein-coupled dopamine receptor D3, which inhibits adenylyl cyclase. D3 dopamine  receptor localises to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions.
Molecular pathology Genetic variants of DRD3 cause essential tremor hereditary type 1 .
References in periodicals archive ?
Specifically, cocaine alters the rhythm of Npas2 and Drd3 as well as the expression of numerous circadian genes in the NAc, most of which are upregulated.
There has not been any report about the association study of TS and DRD3 gene in Han Chinese population.
Based on Chinese Han population genetics data from the database of SNPs (http://www.ncbi.nlm.nih.gov/SNP/; the US National Center for Biotechnology Information), the International HapMap Project (http://www.hapmap.org/), and previous studies, [sup][15],[16] the DRD3 SNP rs6280 locus was selected for gene polymorphism analysis.
A total of 160 sporadic TS patients (including 101 TS patients) involved in pedigree studies and 59 unrelated cases underwent DRD3 SNP rs6280 analysis.
The frequencies of DRD3 rs6280 genotypes C/C, C/T, and T/T were 10.6, 46.9, and 42.5%, respectively, in the TS patient group, and 13.3%, 34.4%, and 52.2%, respectively, in the control group.
Transmission disequilibrium test analysis revealed no transmission disequilibrium in the DRD3 rs6280 SNP among TS nuclear pedigrees, indicating that this locus is not associated with TS ( P = 1; [Table 5]).{Table 5}
Dopamine D3 receptor is mainly located in the region of the brain associated with cognition and affection, and the DRD3 receptor is highly expressed in the mesolimbic dopamine system including the extended amygdala.
previously identified an Association between TS and homozygosity at the DRD3 gene, [sup][15] but this was not replicated in two studies published in the same year.
This study aimed to explore the association between the DRD3 gene rs6280 and TS using both case-controlled study and nuclear pedigrees TDT analysis.
One large study reviewed a great deal of the data collected on the DRD3 and serotonin receptor gene confirm an association of these genes with schizophrenia (Lohmueller, Pearce, Pike, Lander, & Hirschhorn, 2003).
* The work of Amigo, Caselles, and Mico (2013) studies the temporary change of the GFP in relation with the regulating gene DRD3 (like another biological substratum of personality) as a consequence of a suggestion technique, being observed that as much the GFP as the DRD3 respond to a dynamic pattern similar to the one reproduced by the response model.
DRD3 is mainly expressed in the ventral parts of the basal ganglia (e.g., nucleus accumbens).