The first lead compound to emerge from this program is ONC201, an orally active small molecule
DRD2 antagonist, the first one that exhibits a highly specific bi-topic binding to the receptor.
Deficit of
DRD2 receptors in the kidneys, caused by rs1800497 polymorphism disrupts their protective function, which increases the incidence of inflammatory kidney diseases.
Gelernter, "Association of haplotypic variants in
DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent casecontrol and family samples," Human Molecular Genetics, vol.
Hietala, "C957T polymorphism of the dopamine D2 receptor (
DRD2) gene affects striatal
DRD2 availability in vivo," Molecular Psychiatry, vol.
In the prestroke period, genetic and epigenetic factors (such as genotype for DRD1a and
DRD2; Sieber et al., 2014); demographic factors (such as younger age or female gender; Alajbegovic et al., 2014; El Husseini et al., 2012); prior medical history of depression, stroke, or vascular disease (Allan et al., 2013; Andersen et al., 1995); and the relative strength of a patient's social support network (Ayerbe et al., 2011) interact.
Researchers found that two gene variants - FTO and
DRD2 - influenced activity in the brain reward system when looking at pictures of high-calorie foods.
ADH1B*1, ADH1C*2,
DRD2 (141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in los Angeles.
Synonymous mutations in the human dopamine receptor D2 (
DRD2) affect mRNA stability and synthesis of the receptor.
[9,10] Similarly, there is evidence that those who carry particular risk variants of the dopamine
DRD2 gene [11] and AKT1 [2] (a gene involved in determining post-synaptic dopamine signaling) are especially vulnerable to psychosis if they use cannabis heavily.
The genes are the dopamine transporter 1 (DAT1) gene, the three D2-like dopamine receptor (
DRD2, DRD3, and DRD4) genes and the monoamine oxidase-A gene.
Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice.
(49) Although these studies have identified more than twenty genes associated with PTSD such as SLC6A4 (also known as 5HTTLPR),
DRD2, FKBP5, and PACAP, many consider these findings suspect because of how difficult it has been to replicate candidate gene PTSD studies.