DRD2


Also found in: Acronyms.

DRD2

A gene on chromosome 11q23 that encodes G protein-coupled dopamine receptor D2, which inhibits adenylyl cyclase.

Molecular pathology
Defects in DRD2 are associated with myoclonic dystonia.
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References in periodicals archive ?
The first lead compound to emerge from this program is ONC201, an orally active small molecule DRD2 antagonist, the first one that exhibits a highly specific bi-topic binding to the receptor.
Oncoceutics Announces FDA Acceptance of Investigational New Drug Application for Phase I Trial of ONC206
Deficit of DRD2 receptors in the kidneys, caused by rs1800497 polymorphism disrupts their protective function, which increases the incidence of inflammatory kidney diseases.
DETERMINATION OF DOPAMINE RECEPTOR D2 GENE RS1800497 POLYMORPHISM USING REAL-TIME POLYMERASE CHAIN REACTION/DETERMINACIJA POLIMORFIZMA GENA ZA DOPAMINSKI RECEPTOR D2 RS1800497 PRIMENOM REAL-TIME POLIMERAZNE LANCANE REAKCIJE
Gelernter, "Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent casecontrol and family samples," Human Molecular Genetics, vol.
The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction
Hietala, "C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo," Molecular Psychiatry, vol.
The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies
In the prestroke period, genetic and epigenetic factors (such as genotype for DRD1a and DRD2; Sieber et al., 2014); demographic factors (such as younger age or female gender; Alajbegovic et al., 2014; El Husseini et al., 2012); prior medical history of depression, stroke, or vascular disease (Allan et al., 2013; Andersen et al., 1995); and the relative strength of a patient's social support network (Ayerbe et al., 2011) interact.
A review and conceptual model of dopaminergic contributions to poststroke depression
Researchers found that two gene variants - FTO and DRD2 - influenced activity in the brain reward system when looking at pictures of high-calorie foods.
Research Links Genes to Heightened Brain Reward Responses to Foods High in Fat, Sugar
ADH1B*1, ADH1C*2, DRD2 (141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in los Angeles.
Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population/Caracterizacion de polimorfismos de los genes ADH2, ADH3, ALDH2 y CYP2E1 y su relacion con el alcoholismo en una poblacion colombiana
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.
BIOLOGICAL EFFECTS OF THE GROWTH HORMONE GENE POLYMORPHISM IN THE AMERICAN MINK (NEOVISON VISON SCHREB., 1777) - DOES SYNONYMOUS ALWAYS MEAN SILENT
[9,10] Similarly, there is evidence that those who carry particular risk variants of the dopamine DRD2 gene [11] and AKT1 [2] (a gene involved in determining post-synaptic dopamine signaling) are especially vulnerable to psychosis if they use cannabis heavily.
Bridging the gap between research into biological and psychosocial models of psychosis
The genes are the dopamine transporter 1 (DAT1) gene, the three D2-like dopamine receptor (DRD2, DRD3, and DRD4) genes and the monoamine oxidase-A gene.
Association between Tourette Syndrome and the Dopamine D3 Receptor Gene Rs6280
Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice.
Advances in medications and tailoring treatment for alcohol use disorder
(49) Although these studies have identified more than twenty genes associated with PTSD such as SLC6A4 (also known as 5HTTLPR), DRD2, FKBP5, and PACAP, many consider these findings suspect because of how difficult it has been to replicate candidate gene PTSD studies.
Challenges for implementing a PTSD preventive genomic sequencing program in the U.S. military

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