DRD1


Also found in: Acronyms.

DRD1

A gene on chromosome 5q35.1 that encodes G protein-coupled dopamine receptor D1, which is the most abundant dopamine receptor in the CNS. D1 dopamine receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases; they regulate neuronal growth and development, mediate some behavioural responses, and modulate dopamine receptor D2-mediated events.
References in periodicals archive ?
There are also convincing data indicating an association between DRD1 and PA [41].
According to this model, low expression or impaired function of DRD1 and DRD5 increases the level of PA (through reduced inhibitory signalling), while high expression and intact function of DRD2, DRD3 and DRD4 have inhibitory effects on PA (through increased stimulatory transmission).
25] reported a higher frequency of the DRD1 AA genotype in SZ patients than in controls ([chi square]=6.
111] which found increased DRD1 gene expression in patients with first-episode SZ compared with controls, a positive correlation between the level of DRD1 expression and the severity of negative symptoms, and an inverse relationship between the level of DRD1 expression level and the level of aggressiveness of the patient.