DRD1


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DRD1

A gene on chromosome 5q35.1 that encodes G protein-coupled dopamine receptor D1, which is the most abundant dopamine receptor in the CNS. D1 dopamine receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases; they regulate neuronal growth and development, mediate some behavioural responses, and modulate dopamine receptor D2-mediated events.
References in periodicals archive ?
DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques.
There are also convincing data indicating an association between DRD1 and PA [41].
According to this model, low expression or impaired function of DRD1 and DRD5 increases the level of PA (through reduced inhibitory signalling), while high expression and intact function of DRD2, DRD3 and DRD4 have inhibitory effects on PA (through increased stimulatory transmission).
A significant association was observed between a DRD2 allele and age at first sexual intercourse, and an even stronger association was found when both the DRD1 and DRD2 alleles were incorporated into the statistical model.
HTR2C, CHRM2, ADRA2B, HTR6, HTR5A, ADRA2C, HTR7, DRD2, and DRD4; SLC6A4, ADRA1A, HTR1A, ADRA1B, HTR2A, and DRD1; OPRL1, CHRM5, CHRM1, ADRB1, ADRA2A, and HRH1; and CHRM4, CHRM3, KCNH2, SLC6A4, CYP2D6, SCN1A: four clusters of neuronal GPCRs (G-proteincoupled receptors: adrenergic, cholinergic, histamine, and serotonin receptors).
Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR504.
The D1-like family receptors include the DRD1 and DRD5 genes.