DPYSL3

DPYSL3

A gene on chromosome 5q32 that encodes a member of the collapsin response mediator protein family that forms homotetramers and heterotetramers with CRMP1, DPYSL2, DPYSL4 or DPYSL5, interacting with synaptic vesicle protein 2 and SH3A domain of intersectin. DPYSL3 is necessary for signalling by class-3 semaphorins and subsequent cytoskeletal remodelling; it plays a role in axon guidance, neuronal growth cone collapse and cell migration.
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References in periodicals archive ?
Ohshima, "Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish," Developmental Biology, vol.
Chakravarthy, "Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2 O2 toxicity," Journal of Neurochemistry, vol.