DPYSL2

DPYSL2

A gene on chromosome 8p22-p21 that encodes a member of the collapsin response mediator protein family, which forms homo- and heterotetramers. DPYSL2 plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration.  

Molecular pathology
DPYSL2 has been implicated in multiple neurological disorders; hyperphosphorylation of the encoded protein may play a role in the development of Alzheimer's disease.
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Ohshima, "Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish," Developmental Biology, vol.
miRNA ID NOG p value TFP p value miR-145-5p 1 1.66E--02 0.67 2.98E--08 miR-204-5p 5 1.78E--15 0.13 1.05E--02 miR-182-5p 2 1.80E--08 0.20 4.34E--04 miR-567 1 1.66E--02 0.25 4.61E--04 miR-141-3p 2 1.80E--08 0.14 2.05E--03 miR-454-3p 2 1.80E--08 0.11 4.64E--02 miR-590-3p 5 1.78E--15 0.13 2.33E--03 miR-338-3p 2 1.80E--08 0.25 4.61E--04 miR-139-5p 1 1.66E--02 1.00 1.49E--08 miRNA ID Whole target genes miR-145-5p MMP12; ZFP36; KLF4 miR-204-5p DPYSL2; EMP1; SPDEF; LMO7; SLC1A1; ALPL; MMP9; FRAS1 miR-182-5p CAMK2N1; ZFP36; UBE2T; LPHN2; RGS17.
The expression of proteins associated with cytoskeleton and its regulations namely myosin light polypeptide 6 isoform 1 (MYL6), p27BBP protein (eIF6), dihydropyrimidinase-related protein 2 isoform 2 (DPYSL2), caldesmon (CALD1), T-complex protein 1 subunit theta isoform 1 (CCT8) and Chain A, crystal structure of AlixAIP1 (PDCD6IP) were all downregulated by MNQ.