DPP4

(redirected from DPPIV)
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DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
The algorithm does not, at this stage, suggest a role for the newer agents such as the incretins and DPPIV inhibitors.
The search for a treatment for T2DM using GLP-1 has centered on finding a GLP-1 mimetic resistant to degradation by DPPIV or designing a drug that could inhibit DPPIV, thereby prolonging the incretin effect.
There were many papers in favour of DPPIV inhibitors which it was stated offer many advantages like no weight gain but of course they are expensive, not many can afford them and they should be used with caution.
The integrated, automated, high throughput approach that Syrrx has taken to structural biology has yielded numerous otherwise refractory protein structures including DPPIV, histone deacetylase and difficult to solve kinases and nuclear hormone receptors.