CTSC

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CTSC

A gene on chromosome 11q14.2 that encodes cathepsin C, a ubiquitous lysosomal cysteine proteinase that co-ordinates activation of various serine proteinases (e.g., elastase, cathepsin G and granzymes A and B); it also activates neuraminidase and factor XIII. CTSC is highly expressed in the lungs, kidneys and placenta.

Molecular pathology
Defects in CTSC cause Papillon-Lefèvre syndrome, Haim-Munk syndrome and aggressive periodontititis type 1.
References in periodicals archive ?
Like the full circular areas, for each semicircular area, a DPPI can be defined using (1).
When the areas with the highest DPPI values are defined, the point-scan nondestructive techniques will be used to identify the damage in detail.
The DPPI of different areas are calculated using (1) and shown in Figure 8.
Figure 11 shows the DPPI of different full circular areas of the aluminum plate with through-thickness crack.
The surveys were promoted via the DPPI website and disability, parenting and professional organisations.
Enquiries to DPPI's helpline support these findings that it is a common problem for disabled parents to find their needs are not considered appropriately when they approach health and social care professionals.
DPPI is hoping to develop further training for health and social care professionals, and resources for both parents and professionals to improve outcomes for disabled parents.
The DPPI seeks to provide a framework for South Eastern European nations to develop programs and projects leading to strengthened capabilities in preventing and responding to natural and man-made disasters.
Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Macedonia, Greece, Hungary, Moldova, Romania, Serbia, Montenegro, Slovenia and Turkey are the members of the DPPI.
Dipeptidylpeptidase I (Cathepsin C, DPPI) is a cysteine protease that cleaves dipeptide fragments from the amino terminus of a wide variety of proteins.
The substrate specificity of dipeptidylpeptidase I (DPPI, Cahtepsin C), a cysteine protease that removes a dipeptide fragment at the N-terminus of various proteins and peptides, has been tested with a series of dipeptidyl-AMC (AMC = 7-amino-4-methylcoumarin) derivatives.