DPP9 | definition of DPP9 by Medical dictionary
DPP9 A gene on chromosome 19p13.3 that encodes dipeptidyl peptidase 9, a ubiquitously expressed enzyme that cleaves off N-terminal dipeptides. It is highly expressed in the liver, heart and in muscle.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
BXCL701 is designed to activate innate immune cells, specifically macrophages, by inhibiting the dipeptidyl dipeptidases DPP8 and DPP9
, a novel mechanism, and exerts immune stimulatory activity through a pro-inflammatory form of programmed cell death known as pyroptosis.
The nonpeptidomimetics compounds might assume special relevance because they show selectivity for DPP-4 versus other members of the DPP-4-like family of proteases, including DPP-2, DPP-8, and DPP9
, thus avoiding interference with other putatively important functions (although the in vivo functions remain largely unknown), as well as the possibility of undesirable side-effects .