maturity onset diabetes of the young type 8

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maturity onset diabetes of the young type 8

An autosomal dominant (OMIM:609812) condition characterised by diabetes of childhood or early-adulthood onset (usually before 25 years of age), a primary defect in insulin secretion and insulin-independence at the beginning of the disease.

Molecular pathology
Defects in CEL, which encodes a glycoprotein secreted by the exocrine pancreas involved in hydrolysis and absorption of cholesterol, cause maturity onset diabetes of the young type 8.
References in periodicals archive ?
In our earlier study, we used the Reconstruct Programme for the geometric comparison of the DPED area [8].
Optical coherence tomography (OCT) was performed on the OCT Stratus (Zeiss, Jena, Germany) before evaluation to rule out cases of wet AMD and to confirm DPED. During the follow up, it was repeated every six months and whenever the occurrence of neovascular AMD or DPED was suspected.
DPED. The average DPED value at baseline in patients treated with rheohaemapheresis was 6.78[+ or -]3.79 [mm.sup.2]; after 3.5 yearsoffollowup,itdecreasedto4.13[+ or -]3.84[mm.sup.2] (P < 0.001).
Central retinal activity (mainly parafoveal activity between 1.8[degrees] and 7[degrees] of eccentricity or even paramacular activity between 5[degrees] and 13[degrees]) increased in the treated patients with an early decrease or complete disappearance of the DPED area.
In our study, the central retinal activity and BCVA increased in the treated patients with an early decrease or complete disappearance of the DPED area.
Initial results were presented in our previous study [8] in which we also demonstrated the influence of rheohaemapheresis on the reduction of size or disappearance of DPED. If the soft drusen progress into the DPED, which is the normal development of AMD, this pathological change gradually increases and shows no tendency for resorption.
From aircraft to sensor to network architecture, DPED to MI Systems development to individual and collective training from front-end to back-end must take place to ensure that our MI Soldier have the correct skill set required to meet the ever increasing demands of our War Fighting commanders.