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(dē-ŏk″sē-pĭ-rĭ-dĭn′ō-lēn, -lĭn),


A component of the structural matrix of bone, principally found in type 1 collagen as a structural cross link. It provides tensile strength to bone.

When bone resorption exceeds bone rebuilding (for example, in osteoporosis), Dpd is released into the circulation and excreted unchanged in the urine. The detection of elevated levels of Dpd in a concentrated urine specimen is used as a marker of ongoing bone loss in osteoporosis. Reduced levels of Dpd are an indicator of the effectiveness of therapies that reduce bone resorption (e.g., bisphosphonates).

The Dpd urine test is performed by obtaining the first urine voided by a patient on awakening—this ensures that the specimen will be maximally concentrated. The level of Dpd obtained is expressed in nmol of Dpd/mmol of urinary creatinine.


Abbrev. for Diploma in Public Dentistry.
References in periodicals archive ?
Don, from Christchurch, Devon, died on January 4 after skipping hospital appointments as he felt under pressure from DPD managers.
IM Properties is behind the multi-million pound project, which will create a state-of-the-art parcel centre for DPD and a total of 1,300 jobs, as more businesses are attracted to the area.
Station site manager Amir Suleman said workers told him the boy collided with the front of an articulated DPD lorry.
The package is being secured by DPD bomb squad," the statement added.
As a matter of reference, present-day DPD badge numbers surpassed the 10,000 mark several years ago.
DPD started off 30 years ago but has expanded rapidly and has now 30 depots nationwide.
The new facility will add up to 60 new routes initially and gives capacity for DPD to carry on growing in Cardiff for the next five years at least, the company said.
The depot is expected to be completed by early 2016 and, following completion, DPD will take a 25-year lease.
Se evaluaron las concentraciones de DPD de los pacientes del grupo en estudio en la orina recogida 2 horas despues de la primera miccion de la manana, el dia anterior a la cirugia.
The project is part of investment plans announced by DPD in November 2012 and follows a period of unprecedented growth for the parcel carrier, thanks to its unique Predict service which provides customers with a one-hour delivery window so they do not have to wait in all day for their parcel.
But the fact that up to 10 percent of adults are deficient in the vital DPD enzyme, called Dihydropyrimidine dehydrogenase, is bolstering Mr.
Smethwick-based DPD, which already has three sites in the West Midlands, plans to create up to 1,500 UK jobs as part of a PS175 million expansion plan.