DPD

deoxypyridinoline

(dē-ŏk″sē-pĭ-rĭ-dĭn′ō-lēn, -lĭn),

Dpd

A component of the structural matrix of bone, principally found in type 1 collagen as a structural cross link. It provides tensile strength to bone.

When bone resorption exceeds bone rebuilding (for example, in osteoporosis), Dpd is released into the circulation and excreted unchanged in the urine. The detection of elevated levels of Dpd in a concentrated urine specimen is used as a marker of ongoing bone loss in osteoporosis. Reduced levels of Dpd are an indicator of the effectiveness of therapies that reduce bone resorption (e.g., bisphosphonates).

The Dpd urine test is performed by obtaining the first urine voided by a patient on awakening—this ensures that the specimen will be maximally concentrated. The level of Dpd obtained is expressed in nmol of Dpd/mmol of urinary creatinine.

DPD

Abbrev. for Diploma in Public Dentistry.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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Direct Position Determination of Coherently Distributed Sources based on Compressed Sensing with a Moving Nested Array

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