DDX20

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DDX20

A gene on chromosome 1p21.1-p13.2 that encodes a protein which has a conserved Asp-Glu-Ala-Asp (DEAD) motif and is an ATP-dependent RNA helicase belonging to the SMN complex, which plays a key role in spliceosomal snRNP assembly in the cytoplasm. The complex is required for pre-mRNA splicing in the nucleus and may play a role in snoRNP metabolism.
References in periodicals archive ?
The pressure drop across the exchanger was measured by low-pressure transducers (Validyne DP103).
In a study published recently in the Journal of Clinical Investigation, a top-tier journal for discoveries in basic and clinical biomedical research, the team of scientists jointly led by Dr Vinay Tergaonkar, Principal Investigator at IMCB and Dr Alan Prem Kumar, Principal Associate at CSI Singapore and Assistant Professor at the Department of Pharmacology, NUS Yong Loo Lin School of Medicine, uncovered a gene, DP103, which is activated in metastatic breast cancer.
This DP103 gene that we found explains the link and will facilitate doctors in selecting suitable treatments for different cases of breast cancer," said Dr Tergaonkar.
In addition, the study revealed that reducing the levels of DP103 could contain the cancer, shrink the tumour and make patients more amenable to chemotherapy.
"DP103 is a novel biomarker that could help doctors select appropriate treatments for breast cancer patients at an early stage.