aromatic d-amino acid decarboxylase

(redirected from DOPA decarboxylase)
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ar·o·mat·ic d-a·mino ac·id de·car·box·yl·ase

(ar'ō-mat'ik dē a-mē'nō as'id dē'kar-boks'i-lās),
An enzyme that catalyzes the decarboxylation of l-dopa to dopamine, of l-tryptophan to tryptamine, and of l-hydroxytryptophan to serotonin; important in the biosynthetic pathway of catecholamines and melanin.
Farlex Partner Medical Dictionary © Farlex 2012

ar·o·mat·ic d-a·mi·no ac·id de·car·box·y·lase

(ār'ō-mat'ik ă-mē'nō as'id dē'kahr-bok'sil-ās)
An enzyme that catalyzes the decarboxylation of l-dopa to dopamine, of l-tryptophan to tryptamine, and of l-hydroxytryptophan to serotonin; important in the biosynthetic pathway of catecholamines and melanin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
For the most part, available evidence from SPECT and PET studies of dopamine neuron terminal markers in ephedron addicts and in liver disease patients have confirmed the lack of an effect of elevated brain Mn on dopa decarboxylase activity using [[.sup.18]F]-L-dopa PET and on DAT levels in the striatum (Colosimo and Guidi 2009; de Bie et al.
AADC Deficiency is a rare CNS disorder arising from reductions in the enzyme AADC that result from mutations in the dopa decarboxylase gene.
It has been previously shown that [beta]-cells take up L-DOPA (59) and that DOPA decarboxylase is active in pancreatic islet cells (60).
TH activity was measured using [sup.14]C]tyrosine as a substrate and trapping the evolved [sup.14]C[O.sub.2] after coupled decarboxylation with DOPA decarboxylase (Lau et al.
The product is being developed for the treatment of aromatic L-amino acid decarboxylase deficiency (AADC), a rare disease arising from mutations in the dopa decarboxylase (DDC) gene.