DOK5

DOK5

A gene on chromosome 20q13.2 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK5 functions in RET-mediated neurite outgrowth and may be a downstream effector of RET in neuronal differentiation. It upregulates the MAP kinase pathway, and is highly expressed in skeletal muscle, less so in the brain, heart and kidneys.
References in periodicals archive ?
A study conducted by Taiwan Epidemiology Association involving researchers from Institute of Biomedical Sciences of Academia Sinica looked into 10,000 samples provided by Taiwan Biobank and concluded that 50 percent of Taiwanese people have the gene of DOK5, which reputedly affects the sensitivity of insulin, reported Apple Daily.
At the influence of DOK5, insulin, which regulates the metabolism of carbohydrates and fats, tends to increase the amount of glycogen stored in the muscles and liver, thereby helping the human body burn fat, according to researcher Shen Chi-yang.
For example, the ectonucleotide pyrophosphate phosphodiesterase 1 (ENPP1) 121Q variant is implicated in negatively influencing insulin receptor signaling [39] along with the DOK5 gene [40] that increases the risk in both natives in India as well as migrant Asian Indians [39].