DOK3

DOK3

A gene on chromosome 5q35.3 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK3 is a negative regulator of JNK signalling in B-cells via INPP5D/SHIP1; it may modulate ABL1 function. It is expressed in the spleen.
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References in periodicals archive ?
[25] indicated that SNPs in 3r-UTR of docking protein 3 gene (DOK3) may affect the expression of DOK3, then impact on colorectal cancer by altering the miR-370 binding efficiency.
SNPs have been detected in association with an increased risk of CRC affecting either miRNAs (SNPs in miR-196a, miR-149, and pre-miR-27a or in miR-257a, affecting binding to 3'UTR of MBL2 mRNA) [251-253], or the 3'UTR of an mRNA, as in CD86, that alters binding of several miRNAs (in this case, miR-184, miR-200a, miR-212a, miR-337, and miR-582) [254], or DOK3, affecting binding of miR-370 [255].
Singapore, Sept 1, 2014 - (ACN Newswire) - Scientists from A*STAR's Bioprocessing Technology Institute (BTI) have uncovered the crucial role of two signalling molecules, DOK3 and SHP1, in the development and production of plasma cells.
For the first time, the molecule DOK3 was found to play an important role in formation of plasma cells.