DOK2

DOK2

A gene on chromosome 8p21.3 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK2 may modulate IL-4-, IL-2- and IL-3-induced cell proliferation, and may modulate Bcr-Abl signalling, and it attenuates EGF-stimulated MAP kinase activation. It is highly expressed in peripheral white cells, lymph nodes and the spleen.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The 10th full-length album from Drunken Tiger contains 30 tracks on two CDs featuring over a dozen prominent K-pop artists, including BTS' RM, Seventeen's Vernon, rapper Dok2 and SechsKies' Eun Ji-won.
The phosphorylation of these residues results in inducing recruitment of the adaptor protein Dok2 through its binding domain to the phosphorylated tyrosine (PTB), which then initiates the cascade of inhibitory signaling [74].
Brown, "Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells," The Journal of Immunology, vol.
22, English K-pop news site Koreaboo posted a link on Twitter and Facebook of a story titled "Yet another drug scandal involving idol group member sweeps Korea" using photos of Park and fellow rapper Dok2.
This earned the ire of Park who slammed Koreaboo, tweeting, "@koreaboo so yall just gon use me and dok2's pic like that when you know it aint's us?
Recruitment of dynamic complexes comprising NCK adaptor protein 1 (NCK1), RAS p21 protein activator 1 (p120GAP), and P21 protein-activated kinase 1 (PAK1), to TIE2 by the DOKs, especially DOK2, has been attributed to increased cell motility [35].
The veteran singer said he wants to collaborate with artists such as rapper Dok2 and R and B singer Naul.
Rapper Dok2 showed off his wealth on the reality show, "My little old boy" Sunday.
Appearing on a television program, Dok2 had previously complained about his 426-square-meter hotel room being too small and said he planned to move to a bigger place.
Since his debut in 2002, Junggigo, whose real name is Go Jung-gi, has received widespread media attention for his collaboration with renowned local hip-hop artists such as Soul Dive, Eluphant, Mad Clown and Dok2.