DOK1

DOK1

A gene on chromosome 2p13 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK1 modulates integrin activation by competing with talin for the same binding site on ITGB3, and may be a negative regulator of the insulin signalling pathway. It is expressed in the pancreas, heart, leukocytes and spleen.
References in periodicals archive ?
Genes for kinases and kinase inhibitors, such as the CDKN2B, DOK1, KITLG, MAP4K4, NPM1, and PTK2B genes are also included in the panel.
ABCC1 a-f BCL2 a-b BCL2L11 a-d CDNK2B a-b DOK1 a-b EVI1 a-b KITLG a-b MAP4K4 a-d MYB a-d NPM1 a-b PTK2B a-c RUNX1 a-d RUNX1T1 a-b SEPT6 a-d TCL1B a-b WT1 a-d ZBTB16 a-b ZNF198 a-c ZNFN1A1 a-g Table 1.