DOK1

DOK1

A gene on chromosome 2p13 that encodes an enzymatically inert adaptor/scaffolding protein, which provides the docking platform for assembling multimolecular signalling complexes. DOK1 modulates integrin activation by competing with talin for the same binding site on ITGB3, and may be a negative regulator of the insulin signalling pathway. It is expressed in the pancreas, heart, leukocytes and spleen.
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References in periodicals archive ?
Hypermethylation of SYK (spleen tyrosine kinase) or CHFR (checkpoint with fork-head associated and ring finger) occurs specifically in advanced stages of HCC, whereas abnormal DNA methylation of p15, GAAD45a, SFRP1, DOK1, CHRNA3, GSTP1, CRABP1, p16, and RASSF1A occurs at all stages of HCC [20-23].
In comparison with liver tissue from patients who have HCC with or without cirrhosis, HBV or HCV can induce changes in specific genes in the process of DNA repair, cell cycle control, and signal transduction of apoptosis (RASSF1A, GSTP1, CHRNA3, and DOK1 are specific genes that exist in HCC tumors) [17, 18].
Ref number Damage factors Inflammation markers [5] HBV, HCV, NASH IL-6 [6,7] HBV, HCV, NASH TNF-[alpha] [8] HBV, HCV, NASH TGF-[beta], [H.sub.2][O.sub.2], NO [13] Mitochondrial p53 dysfunction [14] NASH CYP2E1 [17,18] HBV, HCV RASSF1A, GSTP1, CHRNA3, DOK1 [27] HBV.HCV, NASH cfDNA [28, 29] HBV, HCV, NASH miRNA [30] HBV, HCV, NASH miRNA-199a, miR-199b, miR-122a, miR-92, miR-222 [31] HBV, HCV, NASH NF-kB, OxLDL [32-35] NASH IL-17 [36-47] NASH Adiponectin [48] NASH Sulfatase 2 [49-51] NASH Adiponectin [52] HBV IL-1[beta], IL-6, CXCL-8, TNF-[alpha] [53-55] HBV HBx [56] HCV PD-L1 [57] HBV, HCV 8-OHdG [58,59] HCV [Fe.sup.2+] Table 2: Summary of antioxidant treatment targets in HCC therapy.
Genes for kinases and kinase inhibitors, such as the CDKN2B, DOK1, KITLG, MAP4K4, NPM1, and PTK2B genes are also included in the panel.
Fernandes et al., "RASSF1A and DOK1 promoter methylation levels in hepatocellular carcinoma, cirrhotic and non-cirrhotic liver, and correlation with liver cancer in brazilian patients," PLOS ONE, vol.