DOG1

DOG1

A gene—Discovered On Gastrointestinal stromal tumours protein 1—that was first identified in the so-called K9 clone, the protein product of which is a highly specific marker for gastrointestinal stromal tumours.
References in periodicals archive ?
Tumour cells were negative for CD117, DOG1, CD1a, SMA and ALK.
Meanwhile, ACC is positive for DOG1, a salivary acini and intercalated duct marker.
The tumor was strongly positive for S-100 protein (fig-4B) and non-reactive for CD117, DOG1, smooth muscle actin and desmin.
Complete histologic analysis of gastrointestinal stromal tumors Content of histologic analysis Our patient Diagnosis and classification according Spindle cell to histologic cell type Size of tumor 5 cm Position (infiltration in mucosa Infiltration or serosa, rupture) in mucosa Number of mitoses/50 VVP 15/50 Proliferation index (Ki in %) 17% c-KIT (focal/diffuse positive, negative, Diffuse/ dot-like positive in cytoplasm) +(positive) DOG1 (focal/diffuse positive, negative) -(negative) CD34 (focal/diffuse positive, negative) Diffuse/+(positive) Desmin (focal/diffuse positive, negative) -(negative) SMA (focal/diffuse positive, negative) -(negative) S-100 (focal/diffuse positive, negative) -(negative) Ki-67 (% of positive cells) 17%
5) We hereby report the clinicopathological features and the role of DOG1 immunomarker for diagnosis in a case of acinic cell carcinoma of nasal cavity.
They may be differentiated from GIST by using immunohistochemistry and they are typically positive for a smooth muscle actin (SMA) and desmin and negative for c-kit, CD34 and DOG1.
Immunohistochemistry showed strong nuclear expression for beta-catenin but was negative for C-KIT, CD34 and DOG1 consistent with a diagnosis of desmoid tumour (3,4,5).
Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis.
Simply text DOG1 followed by a space and the four digit code of your favourite baby followed by your name, address and postcode to 84080.
Jin identified four genes (MSN2, DOG1, HAL1, and INO1) that improve tolerance to ethanol and iso-butanol when they are overexpressed.
The most useful diagnostic immunomarkers are CD117 (c-kit) and DOG1 (discovered on GIST 1), which are both positive in more than 90% of cases.