DOG1

DOG1

A gene—Discovered On Gastrointestinal stromal tumours protein 1—that was first identified in the so-called K9 clone, the protein product of which is a highly specific marker for gastrointestinal stromal tumours.
References in periodicals archive ?
Sox10 and DOG1 expression in primary adnexal tumors of the skin.
Immunohistochemically, the tumor was positive for CD34 [Figure 5] and STAT6 [Figure 6] but negative for S100 protein, smooth muscle actin, and DOG1. Hence, the histological feature was compatible with benign SFT.{Figure 3}{Figure 4}{Figure 5}{Figure 6}
Some Arabidopsis ecotypes presented different ABA sensitivity, via DOG1 (Delay of Germination) expression, with seed dormancy increasing with higher expression.
Cross-species approaches to seed dormancy and germination: conservation and biodiversity of ABA-regulated mechanisms and the Brasssicaceae DOG1 genes.
For the Dog1 and Walking sequences, LSST, IVT, ASLA and our WLSRE tracker are superior to others.
A highly specific marker, DOG1 (discovered on GIST-1), has been started to be used for c-Kit-negative stromal tumors (2).
The immunohistochemical findings showed that CD117 was positive [Figure 1]b, of DOG1 was focally positive, and desmin, SMA, CD34, S-100, SOX10, and p53 were negative, and Ki-67 was 20%+ [Figure 1]c and 1d] suggesting high risk.{Figure 1}
In the presence of spindle cell tumor, cytochemical staining was performed on cellblocks with c-kit (CD117), CD34, DOG1, actin, and S100 antibodies.
"From Day One, it was just like, Tm going to bring my dog1," she says.
Dei Tos et al observed DOG-1 expression in specimens acquired from 139 GIST patients and 438 non-GIST patients and reported that the sensitivity of DOG-1 expression in assessing GIST was up to 97.84%; concurrently, they also observed positive DOG-1 expression in CD-117--negative patients, recommending that a judicious combination of DOG1 and CD-117 may be more beneficial for diagnosis of GIST.