DOG-1A protein, the antibodies to which are highly specific for gastrointestinal stromal tumour (GIST)—a tumour that arises in the interstitial cells of Cajal—and, when used in conjunction with immunohistochemical staining for KIT/CD117, virtually confirm the diagnosis of GIST.
While DOG-1 is the widely preferred name, the protein product is officially (per the HUGO nomenclature committee) known as anoctamin 1; it is encoded by ANO-1 on chromosome 11q13.3. DOG-1/ANO-1 is a transmembrane protein that acts as a calcium-activated chloride channel and is required for normal tracheal development.
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