DNase II | definition of DNase II by Medical dictionary
deoxyribonuclease II (redirected from DNase II)
de·ox·y·ri·bo·nu·cle·ase II , DNase II
an endonuclease that cleaves both strands of native DNA (as well as single-stranded DNA) to produce a mixture of oligodeoxynucleotides, each ending in a 3'-phosphate.
References in periodicals archive
This DNase is more active on double-stranded DNA than on single-stranded DNA and differs from the other three types of endonucleases that are involved in DNA fragmentation (DNase I, DNase II
, and NUC 18) .
Nuclear translocation of DNase II
and acid phosphatase during radiation-induced apoptosis in HL60 cells.
PO may be similar to DNase II
, which functions in eliminating DNA from dead cells or non-self DNA in vivo.
The contents of apoptotic cells are rapidly ingested by professional phagocytes or neighboring cells through mechanisms that are not fully understood (4), and the DNA is consequently completely digested by DNase II
in lysosomes (1).