deoxyribonuclease

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deoxyribonuclease

 (DNase) [de-ok″sĭ-ri″bo-nu´kle-ās]
an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA).

de·ox·y·ri·bo·nu·cle·ase (DNAse, DNAase, DNase),

(de-oks'ē-rī'bō-nū'klē-ās),
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease.

deoxyribonuclease

/de·oxy·ri·bo·nu·cle·ase/ (DNase) (-ri″bo-noo´kle-ās) any nuclease catalyzing the cleavage of phosphate ester linkages in deoxyribonucleic acids (DNA); separated by whether they cleave internal bonds or bonds at termini.

deoxyribonuclease

(dē-ŏk′sē-rī′bō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
DNase.

APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.

de·ox·y·ri·bo·nu·cle·ase

(DNase) (de-oks'ē-rī'bō-nū'klē-ās)
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease

deoxyribonuclease

An enzyme that cuts DNA strands by breaking PHOSPHODIESTER BONDS.

deoxyribonuclease (DNAse)

see NUCLEASE.

deoxyribonuclease

an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA). Abbreviated DNase.
References in periodicals archive ?
Purified human DNase I of known activity (1 [micro]L) was placed on the penciled spot on the CAM sheet with a Pipetman P2 micropipette (Gilson).
The SRED/CAM method is based on the fact that SG shows fluorescence only with unhydrolyzed DNA and not with DNA digested by DNase I (5, 6).
The within- and between-run imprecision studies were performed with the buffer described above and purified human DNase I at two selected concentrations (at the low and high ends of the assay).
There are two predominant DNases in human serum, DNase I and II (5, 9,10).
These properties of the SRED/ CAM method produced better results, and the assay was more rapid and sensitive for determination of DNase I activity in this study than the conventional SRED method.
The SG-SRED method is very sensitive and able to measure DNase I concentrations in the picogram range after incubation of 16 h at 37'C (6).
In conclusion, we have succeeded in developing a sensitive and rapid SRED/CAM DNase I assay method that is convenient and reliable for determining picograms to femtograms of DNase I in 1-[micro]L serum samples within 30 min.
DNase I isn't the only compound that clears cellular debris.
It remains unclear whether simply giving DNase I to lupus patients will help.
By using genetically engineered mice to measure the effects of DNase I, Moroy and his colleagues have opened a new area of investigation, according to Hess.
DNase I treatment thinned the lung mucus of all of the patients participating in the new study, Crystal and his colleagues found.
Crystal and his colleagues reported early results from the DNase I study at a conference on cystic fibrosis last year (SN: 3/2/91, p.