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 (DNase) [de-ok″sĭ-ri″bo-nu´kle-ās]
an enzyme that catalyzes the hydrolysis (depolymerization) of deoxyribonucleic acid (DNA).
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

de·ox·y·ri·bo·nu·cle·ase (DNAse, DNAase, DNase),

Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease.
Farlex Partner Medical Dictionary © Farlex 2012


(dē-ŏk′sē-rī′bō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


(DNase) (de-oks'ē-rī'bō-nū'klē-ās)
Any enzyme (phosphodiesterase) hydrolyzing phosphodiester bonds in DNA.
See also: endonuclease, nuclease
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


An enzyme that cuts DNA strands by breaking PHOSPHODIESTER BONDS.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

deoxyribonuclease (DNAse)

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatment.
In this study, we illustrated the following: ventilation with high-tidal volume causes lung injury and inflammation in mice; NETs increase in the lung of the VILI animal model upon the elevation of known NET-associated proteins and extracellular DNA; pretreatment of NET degradation with DNase I alleviates the preceding lung injury, which means that NET formation has an adverse effect on the development of VILI; and TLR4 is involved in NET formation in VILI in mice.
A previous study concluded that DNase I, instead of proteases, degrades NETs [34].
(2001) DNase I mediates internucleosomal DNA degradation in human cells undergoing drug-induced apoptosis.
Bovine DNase I: gene organization, mRNA expression, and changes in the topological distribution of the protein during apoptosis in lens epithelial cells Biochem.
DNase I and fragmented chromatin during nuclear degradation in adult bovine lens fibersMol.
A DNase kit was then used to test all of the DNase I standards, following the same protocol as with the RNase.
Human DNase I was purified from urine as described previously (8).
An assay reagent set for DNase I activity was prepared in two steps: production of a gel plate for keeping the CAM wet, and preparation of CAM containing reaction buffer.
To measure whether ample DNase I can clear the decks and prevent such an onslaught, the researchers created mice that lack the enzyme and compared them with healthy mice.
Moroy and his colleagues examined 69 mice missing the gene that encodes DNase I, as well as 78 others that had a partial enzyme deficiency and 37 that had a full complement of the enzyme.
DNase I is a naturally occurring body enzyme that chops up DNA, a major constituent of the sticky phlegm that accumulates in the lungs and other organs of cystic fibrosis patients.