DNMT3L

A gene on chromosome 21q22.3 that encodes a nuclear protein with similarity to DNA methyltransferases, which is not thought to function as a DNA methyltransferase, as it lacks the amino acid residues needed for methyltransferase activity, but does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is required for establishing maternal genomic imprints. It also mediates transcriptional repression by interacting with histone deacetylase 1.

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DNMT3

References in periodicals archive ?

Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. J Biol Chem.2006;281(36):25893-902.

Mas alla de las moleculas ... Lo que los clinicos desconocen: acortando brechas

Four main variants of DNMTs are found in humans, namely DNMT1, DNMT3A, DNMT3B, and DNMT3L, to mediate the methylation process.

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Furthermore, IPA identified DNMT3L as one of the top five upstream regulators of genes overlapping DMRs in newborn cord blood (p = 2.1 x [10.sup.-3] as calculated by IPA using the right-tailed Fisher's exact test) (Table 3).

Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children

Epigenetic modification plays an important role in gametogenesis, it has been reported the absence of DNA methyltransferase 3-like (Dnmt3L) caused overall loss of cytosine-guanine (CG) and non-CG methylation in germ cells and resulted in infertility.

Hemicastration induced spermatogenesis-related DNA methylation and gene expression changes in mice testis

A total of 5 different forms of DNMT, namely, DNMT1, DNMT2, DNMT3a, DNMT3b, and DNMT3L, have been defined in mammals.

Studying the Association between Sudden Hearing Loss and DNA N-Methyltransferase 1 (DNMT1) Genetic Polymorphism

El4.5'te, erkek germ hucrelerinde DNA metiltransferaz DNMT3A ve DNMT3B, ve kofaktor DNMT3L (DNA methyltransferase 3-like) aktivasyonu ile global de novo DNA metilasyon orani yaklasik %10'dan %50'ye kadar hizla yukselmektedir (11).

KAZANILMIS EPIGENETIK DEGISIKLIKLERIN KALITIMI VE HASTALIKLARA YATKINLIKTAKI ROLU/INHERITANCE OF ACQUIRED EPIGENETIC MODIFICATIONS AND ITS ROLE IN DISEASE SUSCEPTIBILITY

Memelilerde 4 farkli DNMT enzimi (DNMT1, DNMT3A, DNMT3B, DNMT3L) bilinmektedir ve kanser gelisiminde en onemli olani DNMT1'dir (13).

Epigenetik Degisiklikler ve Mesane Kanseri Arasindaki Iliski/The Relationship between Bladder Cancer and Epigenetic Alterations

Genes encoding proteins related to immune pathway (DUSP10), cell signaling (PLA2G4A, PRKCD), epigenetic regulation (DNMT3L, H2AFZ, MBD3), cell differentiation (LIF), cell adhesion and signal transduction (ITGAV), metabolic pathway (RASL 12), and cell apoptosis (FAS) were differentially expressed among the three groups, consistent with the results determined using RNA-Seq.

Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression

By contrast, DNMT3L has no catalytic domain and predominantly functions as an accessory protein to DNMT3A [29].

Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis

Further insight will be provided using protein interaction screens using epitope-tagged versions of all active Dnmts as well as the known regulators URHF1 and Dnmt3L in XX and XY ES cells.

XXDNAM-How does the X chromosome regulate DNA methylation in pluripotent stem cells?

The de novo DNA methytransferases DNMT3A and DNMT3B, as well as the co-factor DNMT3L, are major players in the general mechanisms underlying DNA methylation, (72-75) but the locus specificity is not explained by this alone.

Mammalian-specific genomic functions: newly acquired traits generated by genomic imprinting and LTR retrotransposon-derived genes in mammals

A regulatory factor similar to DNMT3 enzyme is placed beside these enzymes which is referred to as DNMT3L [18].