DNMT3B


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DNMT3B

A gene on chromosome 20q11.2 that encodes a DNA methyltransferase thought to function in de novo methylation, rather than maintenance methylation. The protein localises to the cytoplasm and nucleus; its expression is developmentally regulated.

Molecular pathology
DNMT3B mutations cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
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Analysis of gene expression of main genes including MEG3, DNMT1, DNMT3A, DNMT3B and reference gene GAPDH in time dependent manner was done in 12 h, 24 h and 48 h under treatment of DNC in HuH-7 and HepG2 cell lines (Fig.
Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.
DNMT3B C/T polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
We estimated the associations between variants in eight genes: DNMT1, DNMT3A, DNMT3B, DNMT3L, TET1, TET2, TET3, and TDG, and LINE1 and AluYb8 methylation using linear regression models described above.
Increased levels of DNMT3L in cancer could lead to aberrant DNA methylation, and subsequent misregulation of a subset of genes, because of its stimulatory effect on DNMT3A and DNMT3B.
The methylation at the 5'-methylcytosine is catalyzed by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B (Bestor 2000; Chen and Li 2004).
Apart from AS3MT and N6AMT1, we have previously reported evidence that genetic variation in DNA methyltransferases DNMT1 and DNMT3B influences arsenic metabolism efficiency, and similar to N6AMT1, associations with these methyltransferases were weaker than associations with AS3MT variants (Engstrom et al.
DNMT3A, a de novo DNA methyltransferase, establishes the patterns of methylation in early embryonic development, along with DNMT3B, and cooperates with DNMT1 to maintain the methylation of repetitive sequences such as LINE-1 and Alu elements (Jones and Liang 2009).
KEY WORDS: cadmium, DNMT1, DNMT3B, epigenetic, genotype, LINE-1, MLH1, p16, pyrosequencing.
In addition to its effect on SAM availability, arsenic can directly interact with DNMTs and inhibit their activities, Several studies have shown that arsenic exposure leads to a dose-dependent reduction of mRNA levels and activity of DNMTs both in vitro and in vivo, including DNMT1, DNMT3A, and DNMT3B (Ahlborn et al.