DNMT3

DNMT3

There is no gene currently designated as DNMT3; see DNMT3A, DNMT3B, DNMT3L.
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Abbreviations: APCm, mutated APC gene; BRAFm, mutated BRAF gene; BRAFwt, BRAF wild type; CIMP, CpG island methylator phenotype; CIMPH, CIMP high; CIMPL, CIMP low; CIMP-, CIMP negative; CIN, chromosomal instability; DNMT3, DNA methyltransferase-3; [IGFBP.
DNA metil transferazdan bini [bir DNMT1, bir DNMT2, uc DNMT3 (DNMT3a/3b ve DNMT3L)]S-adenozil metiyoninden bir metil grubunun sitozine transferini kataliz etmektedir.
En mamiferos la metilacion del DNA se lleva a cabo por tres metiltransferasas de DNA (DNMT), DNMT1, DNMT3 y DNMT3b.
Three different families of DNMT genes have been identified so far: DNMT1, DNMT2, and DNMT3 (Robertson and Wolffe 2000).
DNMT3 family is composed by DNMT3A, DNMT3B and DNMT3L located, respectively, at 2p23, 20q11.
Cloning, expression and chromosome locations of the human DNMT3 gene family.
0001) for RUNX3 gene but not to DNMT3A, DNMT3B e DNMT3 genes on CpG islands analyzed.