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DNMT3 enzyme is a de novo methyltransferase  and DNMT1 is mainly involved in the maintaining of DNA methylation in dividing somatic cells .
Chedin, "The DNMT3 family of mammalian de novo DNA methyltransferases," Progress in Molecular Biology and Translational Science, vol.
The knockdown of both [DNMT3b.sup.(-/-)] and [DNMT3a.sup.(-/-)] mice embryonic stem cells are not observed to be compatible with life due to the extensive disruption of normal developmental process , confirming a crucial role of DNMT3 enzymes in embryonic development.
(2002) Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice.
Abbreviations: APCm, mutated APC gene; BRAFm, mutated BRAF gene; BRAFwt, BRAF wild type; CIMP, CpG island methylator phenotype; CIMPH, CIMP high; CIMPL, CIMP low; CIMP-, CIMP negative; CIN, chromosomal instability; DNMT3, DNA methyltransferase-3; [IGFBP.sup.CG], IGFBP methylation; KRASm, mutated KRAS gene; [MGMT.sup.CG], MGMT methylation; [MLH1.sup.CG], MLH1 methylation; MSIH, microsatellite unstable; MSS, microsatellite stable; MVHP, microvesicular hyperplastic polyp; [P16.sup.CG], P16 methylation; SSA/P, sessile serrated adenoma/polyp; TA, tubular adenoma; TSA, traditional serrated adenoma; TVA, tubulovillous adenoma.
The DNMT3 family provides the CpG methylation through de novo path, whilst the DNMT1 family maintains the methylation models during replication .
DNA metil transferazdan bini [bir DNMT1, bir DNMT2, uc DNMT3 (DNMT3a/3b ve DNMT3L)]S-adenozil metiyoninden bir metil grubunun sitozine transferini kataliz etmektedir.
Three different families of DNMT genes have been identified so far: DNMT1, DNMT2, and DNMT3 (Robertson and Wolffe 2000).
There was a statistically significant difference among diffuse-type and intestinal-type samples (p=0.0418) and among normal and tumour tissues (p<0.0001) for RUNX3 gene but not to DNMT3A, DNMT3B e DNMT3 genes on CpG islands analyzed.
Accordingly, both natural and synthetic resveratrol derivatives, such as resveratrol-salicylate, can concurrently act as DNA methylation blockers and antioxidant partners by inhibiting DNMT3 and DNMT3b enzymes and by decreasing the expression of myeloperoxidase (MPO), respectively .
(8-13) The DNA methyltransferase 3-like (DNMT3L) gene is a member of the DNA methyltransferase 3 (DNMT3) gene family (14) and regulates DNA methylation by interacting with the de novo methyltransferases DNA methyltransferase 3A (DNMT3A) and DNA methyltransferase 3B (DNMT3B).
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